Results 51 to 60 of about 1,466,572 (302)

Hepatitis C Virus Reinfection Following Treatment Among People Who Use Drugs [PDF]

Clinical Infectious Diseases, 2013
Most new cases of hepatitis C virus (HCV) infections in the developed world are associated with injection drug use. However, treatment for people who inject drugs (PWID) is controversial, as successful treatment risks being followed by new infection.
Grady, Bart P., Schinkel, Janke, Thomas, Xiomara V., Dalgard, Olav   +3 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

“If everyone knew about this, how many lives could we save?”: Do drug suppliers have a role in reducing overdose risk?

Drug and Alcohol Dependence Reports
Introduction: An unpredictable illicit drug supply is driving high levels of overdose death in North America. Prior research has demonstrated the importance of involving people who use drugs in harm reduction intervention design and implementation.
Bethany Hedden-Clayton, Jes Cochran, Jennifer J. Carroll, Alex H. Kral, Grant Victor, Erin Comartin, Bradley Ray   +6 more
doaj   +1 more source

Use of the painDETECT tool in rheumatoid arthritis suggests neuropathic and sensitization components in pain reporting. [PDF]

, 2014
Rheumatoid arthritis (RA) is an inflammatory autoimmune condition typified by systemic inflammation targeted toward synovial joints. Inhibition of proinflammatory networks by disease-modifying antirheumatic drugs, eg, methotrexate and biologic therapies,
Ahmed, S, Harrison, A, Magan, T, Sofat, N, Vargas, M   +4 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Overdose Prevention and Response A guide for people who use drugs and harm reduction staff in Eastern Europe and Central Asia [PDF]

, 2009
Provides an overview of the drug overdose problem in Eastern Europe and Central Asia; describes overdose symptoms, factors that affect overdose risk, prevention methods, and step-by-step responses to an overdose.
Curtis, Matt, Guterman, Lydia
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Intravenous fentanyl use among people who inject drugs in Australia

Drug and Alcohol Review, 2018
AbstractIntroduction and AimsThere is a current epidemic of pharmaceutical opioid (PO) misuse, particularly fentanyl and fentanyl analogues, globally. Fentanyl is a highly potent synthetic opioid with rapid onset and significantly higher risk of overdose compared with other opioids. Contexts and correlates of fentanyl use among people who inject drugs (
Geddes, L, Iversen, J, Memedovic, S, Maher, L   +3 more
openaire   +3 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Community contexts and knowledge: accountability, leadership and meaningful involvement of communities in Programme Science

Journal of the International AIDS Society
Introduction A Programme Science approach that prioritizes populations who will benefit most and ensuring resources are allocated to programmes that meet the needs of those populations will bring an equity focus to research.
Ruth Morgan Thomas, Andrew Spieldenner, Erika Castellanos, Judy Chang, Jules Kim   +4 more
doaj   +1 more source