Results 71 to 80 of about 1,506,029 (346)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

‐19 pandemic for people who use drugs [PDF]

, 2023
The COVID-19 pandemic triggered widespread socioeconomic hardship, disproportionately impacting disadvantaged populations. People who use illicit drugs are more likely to experience unemployment, homelessness, criminal justice involvement and poorer ...
P. Dietze, Dietze, Paul, Walker, Shelley, Higgs, Peter, Stoové, M., C. Treloar, J. Doyle, Treloar, C., Doyle, J., P. Higgs, Hellard, M., M. Hellard, Maher, L., B. Ward, Rathnayake, K., S. Walker, M. Stoové, K. Rathnayake, Ward, B., L. Maher   +19 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

“If everyone knew about this, how many lives could we save?”: Do drug suppliers have a role in reducing overdose risk?

Drug and Alcohol Dependence Reports
Introduction: An unpredictable illicit drug supply is driving high levels of overdose death in North America. Prior research has demonstrated the importance of involving people who use drugs in harm reduction intervention design and implementation.
Bethany Hedden-Clayton, Jes Cochran, Jennifer J. Carroll, Alex H. Kral, Grant Victor, Erin Comartin, Bradley Ray   +6 more
doaj   +1 more source

Moving towards a continuum of safer supply options for people who use drugs: A qualitative study exploring national perspectives on safer supply among professional stakeholders in Canada

Substance Abuse Treatment, Prevention, and Policy, 2022
Background Novel public health interventions are needed to address the toxic drug supply and meet the needs of people who use drugs amidst the overdose crisis.
Annie Foreman-Mackey, B. Pauly, Andrew Ivsins, K. Urbanoski, Manal Mansoor, Geoff Bardwell   +5 more
semanticscholar   +1 more source

Detaining people who use drugs in Cambodia: A dual-track system

International Journal of Drug Policy, 2021
Reports focusing on drug detention centres in Cambodia have predominantly been concerned with documenting conditions and human rights abuses in the government centres, while highlighting the failure of the Royal Government of Cambodia (RGC) to adopt a human rights and public health-based approach to substance use issues.
openaire   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

'Zombie drugs':Dehumanising news frames and public stigma towards people who use drugs [PDF]

Background:News media is an important determinant of public understanding of drug policy topics. Recent media reporting around the use of synthetic drugs such as xylazine makes frequent use of non-human metaphors, including reference to the effects of ...
Maynard, Olivia M, Maynard, O M, Atkinson, Amanda, Montgomery, C, Nicholls, J, Sumnall, Harry, Holland, A, Montgomery, Cathy, Nicholls, James, Sumnall, H R, Holland, Adam, Atkinson, AM   +11 more
core   +1 more source

Intersecting substance use treatment and harm reduction services: exploring the characteristics and service needs of a community-based sample of people who use drugs

Harm Reduction Journal, 2022
Background Substance use treatment and harm reduction services are essential components of comprehensive strategies for reducing the harms of drug use and overdose.
N. Krawczyk, Sean T. Allen, K. Schneider, Keisha T. Solomon, Hridika Shah, Miles Morris, S. Harris, S. Sherman, B. Saloner   +8 more
semanticscholar   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source