PLoS ONE, 2020 Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of pepsin in HPSCC is not clear.
Kai Niu, Chunjie Guo, Shuyuan Yu
exaly +3 more sources
Research note: Extraction, purification, physicochemical, and biochemical properties of pepsin isolated from geese forestomachs fed under intensive and extensive conditions [PDF]
Poultry ScienceThis Research Note reports the isolation and basic characterization of pepsin obtained from the forestomach of geese raised under intensive and extensive rearing systems.
Pelin Beyazgul +7 more
doaj +2 more sources
Analyzing pepsin degradation assay conditions used for allergenicity assessments to ensure that pepsin susceptible and pepsin resistant dietary proteins are distinguishable. [PDF]
PLoS ONE, 2017 The susceptibility of a dietary protein to proteolytic degradation by digestive enzymes, such as gastric pepsin, provides information on the likelihood of systemic exposure to a structurally intact and biologically active macromolecule, thus informing on
Rong Wang +8 more
doaj +1 more source
Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. [PDF]
PLoS ONE, 2018 There is evidence that pepsin can aggravate tonsil hypertrophy. Pepstatin is a potent inhibitor of pepsin activity and could protect patients against reflux tonsil hypertrophy by inhibiting pepsin.
Jin Hyun Kim +4 more
doaj +1 more source
The In Vitro Effect of Acidic-Pepsin on Nuclear Factor KappaB Activation and Its Related Oncogenic Effect on Normal Human Hypopharyngeal Cells. [PDF]
PLoS ONE, 2016 Extra-esophageal carcinogenesis has been widely discussed in relation to the chronic effects of laryngopharyngeal reflux and most prominently with pepsin historically central to this discussion.
Clarence T Sasaki +2 more
doaj +1 more source
Variability and accuracy of multiple saliva pepsin measurements in laryngopharyngeal reflux patients
Journal of Otolaryngology - Head and Neck Surgery, 2023 Objective To study the variability and diagnostic value of multiple salivary pepsin measurements in the detection of laryngopharyngeal reflux (LPR).
Jerome R. Lechien, Francois Bobin
doaj +1 more source
Sensors, 2020 Salivary pepsin is a promising marker for the non-invasive diagnosis of laryngopharyngeal reflux (LPR). For reliable results regarding pepsin in saliva, it is critical to standardize the collection, storage, and pre-processing methods.
Young Ju Lee +5 more
doaj +1 more source
Extra-Esophageal Pepsin from Stomach Refluxate Promoted Tonsil Hypertrophy. [PDF]
PLoS ONE, 2016 Gastroesophageal reflux is associated with numerous pathologic conditions of the upper aerodigestive tract. Gastric pepsin within reflux contributes to immunologic reactions in the tonsil.
Jin Hyun Kim +7 more
doaj +1 more source
Do Lipids Influence Gastrointestinal Processing: A Case Study of Major Soybean Allergen Gly m 4
Membranes, 2021 Previously, we have demonstrated that Gly m 4, one of the major soybean allergens, could pass through the Caco-2 epithelial barrier and have proposed a mechanism of sensitization.
Ekaterina I. Finkina +4 more
doaj +1 more source
Allergies, 2023 Celiac peptide-generating α- and γ-gliadins consist of a disordered N-terminal domain extended by an α-helical-folded C-terminal domain. Celiac peptides, primarily located along the disordered part of α- and γ-gliadin molecules, are nicely exposed and ...
Annick Barre +2 more
doaj +1 more source