Results 91 to 100 of about 1,752,184 (298)

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases [PDF]

, 2016
Tae-ho Jang, In-Hye Lim, Chang Min Kim, Jae Young Choi, Eunae Kim, Tae Jin Lee, Hyun Ho Park   +6 more
openalex   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Improved Synthesis and Isolation of Bedaquiline

ACS Omega, 2020
Hlengekile Lubanyana, Per I. Arvidsson, Thavendran Govender, Hendrik G. Kruger, Tricia Naicker   +4 more
doaj   +1 more source

Inherent fast inactivation particle of Nav channels as a new binding site for a neurotoxin

The EMBO Journal
Neurotoxins derived from animal venoms are indispensable tools for probing the structure and function of voltage-gated sodium (Nav) channels. Utilizing a novel centipede peptide toxin called rpTx1, we show that the “inherent inactivation particle” of Nav
Xi Zhou, Haiyi Chen, Shuijiao Peng, Yuxin Si, Gaoang Wang, Li Yang, Qing Zhou, Minjuan Lu, Qiaoling Xie, Xi He, Meijing Wu, Xin Xiao, Xiaoqing Luo, Xujun Feng, Wenxing Wang, Sen Luo, Yaqi Li, Jiaxin Qin, Minzhi Chen, Qianqian Zhang, Weijun Hu, Songping Liang, Tingjun Hou, Zhonghua Liu   +23 more
doaj   +1 more source

A comparative study of the ability of calcitonin gene‐related peptide and adrenomedullin_13–52 to modulate microvascular but not thermal hyperalgesia responses [PDF]

, 2000
Duc Quyen Chu, ManKin Choy, Paul Foster, Thong Cao, Susan D. Brain   +4 more
openalex   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Tumor-associated macrophages in clear cell renal cell carcinoma express both gastrin-releasing peptide and its receptor: a possible modulatory role of immune effectors cells [PDF]

, 2009
Jens Bedke, Bernhard Hemmerlein, Christina Perske, Andreas J. Gross, Markus Heuser   +4 more
openalex   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source