Results 91 to 100 of about 3,466,843 (390)

Free energy barrier for melittin reorientation from a membrane-bound state to a transmembrane state [PDF]

, 2013
An important step in a phospholipid membrane pore formation by melittin antimicrobial peptide is a reorientation of the peptide from a surface into a transmembrane conformation.
Allende D., Almeida P. F., Andersson M., Berneche S., Chen F. Y., Constantinescu I., de Jongh H. H. J., Glattli A., Gordon-Grossman M., Hess B., Hristova K., Huang H. W., Huang H. W., Humphrey W., Irudayam S. J., Irudayam S. J., Jämbeck J. P. M., Klocek G., Kuchinka E., Ladokhin A. S., Lam K. L. H., Lin J. H., Lu N. Y., Manna M., Matsuzaki K., Max L. Berkowitz, Mihajlovic M., Mihajlovic M., Mihajlovic M., Naito A., Nguyen L. T., Pott T., Pott T., Qiu W. H., Raghuraman H., Raghuraman H., Raghuraman H., Raghuraman H., Santo K. P., Sengupta D., Sheeba J. Irudayam, Tobias Pobandt, Torrie G. M., Ulmschneider J. P., Vivcharuk V., Wessman P., Wiedman G., Wimley W. C., Wimley W. C., Yang L., Yeh I. C.   +50 more
core   +3 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors

Molecular Cancer, 2018
The potential for adoptive cell immunotherapy as a treatment against cancers has been demonstrated by the remarkable response in some patients with hematological malignancies using autologous T cells endowed with chimeric antigen receptors (CARs ...
Erhao Zhang, Jieyi Gu, Hanmei Xu
doaj   +1 more source

Increased serum levels of procollagen type III peptide in severely injured patients [PDF]

, 1993
Objectives: To determine the serum concentrations of procollagen type in peptide in severely injured patients with different outcomes and to evaluate the relationship between serum procollagen type III peptide concentrations, sources of increased ...
Duswald, Karl-Heimo, Jochum, Marianne, Lenk, Susann, Nast-Kolb, Dieter, Schweiberer, Leonhard, Trupka, Arnold, Waydhas, Christian   +6 more
core  

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli

BMC Genomics
Background Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs).
Victor J. Pai, Calvin J. Lau, Almudena Garcia-Ruiz, Cynthia Donaldson, Joan M. Vaughan, Brendan Miller, Eduardo V. De Souza, Antonio M. Pinto, Jolene Diedrich, Narender R. Gavva, Shan Yu, Christopher DeBoever, Shane R. Horman, Alan Saghatelian   +13 more
doaj   +1 more source

Candidalysin is a fungal peptide toxin critical for mucosal infection

Nature, 2016
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses.
D. Moyes, Duncan W. Wilson, J. Richardson, S. Mogavero, Shirley X. Tang, J. Wernecke, Sarah Höfs, R. Gratacap, J. Robbins, Manohursingh Runglall, C. Murciano, M. Blagojevic, S. Thavaraj, Toni M. Förster, Betty Hebecker, L. Kasper, Gema Vizcay, S. Iancu, Nessim Kichik, A. Häder, O. Kurzai, Ting Luo, Thomas Krüger, O. Kniemeyer, E. Cota, O. Bader, R. Wheeler, T. Gutsmann, B. Hube, J. Naglik   +29 more
semanticscholar   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Crystal structure of 2-(ethoxycarbonyl)-2-(2-nitro-1-phenylethyl)-3-oxopyrrolidinium chloride, C15H19N2O5Cl

Zeitschrift für Kristallographie - New Crystal Structures, 2016
C15H19N2O5Cl, triclinic, P1̅ (no. 2), a = 8.2232(9) Å, b = 8.5833(10) Å, c = 12.5916(13) Å, β = 100.713(5)°, V = 833.39 Å3, Z = 2, Rgt(F) = 0.0331, wRref(F2) = 0.0870, T = 173 K.
Bhatt Nilay, Samipillai Marivale, Das Sukant Kishore, Kruger Hendrik Gert, Govender Thavendran, Maguire Glenn E.M.   +5 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source