Results 91 to 100 of about 2,341,910 (347)
Clinical Medicine Insights: Oncology, 2008 The major problems of traditional chemotherapy are non-selectivity and non-specificity, resulting in severe toxic side effects. Peptides are a new-generation of drug-delivery vector to increase efficacy of this therapy and avoid the resulting damage. The
Li-Chun Sun +4 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Cell Reports, 2021 Summary: The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and the cAMP-regulated transcription co-activators 1–3 (CRTC1–3). Differentiation is dysregulated in melanomas, although the contributions of CRTC proteins is unclear.
Jelena Ostojić +6 more
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THE ACTION OF ALKALIES ON PEPTIDES AND ON KETOPIPERAZINES [PDF]
, 1925 P.A. Levene, Mimosa H. Pfaltz
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EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Über den Abbau einiger Aminosäuren und Peptide im Organismus des Hundes. [PDF]
, 1906 Emil Abderhalden, Yutaka Teruuchi
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Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
CELL WALL LYSIS AND THE RELEASE OF PEPTIDES IN BACILLUS SPECIES1 [PDF]
, 1959 R. E. Strange
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Vergleichende Untersuchung der freien Aminosäuren und Peptide während der Raupen- und Puppenentwicklung verschiedener Genotypen von Ephestia kühniella [PDF]
, 1956 Pei Shen Chen, Alfred Kühn
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