Results 101 to 110 of about 2,268,571 (366)
Zeitschrift für Kristallographie - New Crystal Structures, 2016 C16H20N2O4S, monoclinic, P21/n (no. 14), a = 9.229(2) Å, b = 16.995(4) Å, c = 11.084(3) Å, β = 99.985(11)°, V = 1712.3(8) Å3, Z = 4, Rgt(F) = 0.0393, wRref(F2) = 0.1081, T = 173.
Bhatt Nilay +5 more
doaj +1 more source
Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors
Molecular Cancer, 2018 The potential for adoptive cell immunotherapy as a treatment against cancers has been demonstrated by the remarkable response in some patients with hematological malignancies using autologous T cells endowed with chimeric antigen receptors (CARs ...
Erhao Zhang, Jieyi Gu, Hanmei Xu
doaj +1 more source
An antitumor peptide RS17‐targeted CD47, design, synthesis, and antitumor activity
Cancer Medicine, 2021 Background CD47 is a widely expressed transmembrane protein located on the surface of somatic cells. It mediates a variety of cellular processes including apoptosis, proliferation, adhesion, and migration.
Xinmin Wang +3 more
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli
BMC GenomicsBackground Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs).
Victor J. Pai +13 more
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Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Naturally Occurring Oxazole-Containing Peptides
Marine Drugs, 2020 Oxazole-containing peptides are mostly of marine origin and they form an intriguing family with a broad range of biological activities. Here we classify these peptides on the basis of their chemical structure and discuss a number of representatives of ...
Jessica T. Mhlongo +3 more
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Molecular Oncology, EarlyView.In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen +13 more
wiley +1 more source
A Multi-Modal Contrastive Diffusion Model for Therapeutic Peptide Generation [PDF]
arXiv, 2023 Therapeutic peptides represent a unique class of pharmaceutical agents crucial for the treatment of human diseases. Recently, deep generative models have exhibited remarkable potential for generating therapeutic peptides, but they only utilize sequence or structure information alone, which hinders the performance in generation.
arxiv
Zeitschrift für Kristallographie - New Crystal Structures, 2016 C15H19N2O5Cl, triclinic, P1̅ (no. 2), a = 8.2232(9) Å, b = 8.5833(10) Å, c = 12.5916(13) Å, β = 100.713(5)°, V = 833.39 Å3, Z = 2, Rgt(F) = 0.0331, wRref(F2) = 0.0870, T = 173 K.
Bhatt Nilay +5 more
doaj +1 more source