Results 121 to 130 of about 2,268,571 (366)

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

CD146 is required for VEGF-C-induced lymphatic sprouting during lymphangiogenesis

Scientific Reports, 2017
VEGF-C is essential for lymphangiogenesis during development and tumor progression. VEGFR-3 is the well-known cognate receptor of VEGF-C to regulate lymphatic migration and proliferation, but the receptor of VEGF-C in regulating lymphatic sprouting, the ...
Huiwen Yan, Chunxia Zhang, Zhaoqing Wang, Tao Tu, Hongxia Duan, Yongting Luo, Jing Feng, Feng Liu, Xiyun Yan   +8 more
doaj   +1 more source

Solution structure of a bacterial microcompartment targeting peptide and its application in the construction of an ethanol bioreactor [PDF]

, 2014
Targeting of proteins to bacterial microcompartments (BMCs) is mediated by an 18-amino-acid peptide sequence. Herein, we report the solution structure of the N-terminal targeting peptide (P18) of PduP, the aldehyde dehydrogenase associated with the 1,2 ...
Brown, Ian R., Frank, Stefanie, Howard, Mark J., Lawrence, Andrew D., Lee, Matthew J., Mulvihill, Daniel P., Newnham, Sarah, Prentice, Michael B., Rowe, Michelle L., Warren, Martin J., Xue, Wei-Feng   +10 more
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Structural Stability and Immunogenicity of Peptides [PDF]

arXiv, 2010
We investigated the role of peptide folding stability in peptide immunogenicity. It was the aim of this thesis to implement a stability criterion based on energy computations using an AMBER force field, and to test the implementation with a large dataset.
arxiv  

Sequence-dependent modification of Trp by the Pmc protecting group of Arg during TFA deprotection [PDF]

, 1994
The extent of transfer of the Pmc protecting group from the guanidine group of arginine to the side chain of tryptophan depends on the spacial distance of these side chains.
. J Peptide Prmcin, Ri &apos
core  

Development of a hypersensitive periodate-cleavable amino acid that is methionine- and disulfide-compatible and its application in MHC exchange reagents for T cell Characterisation [PDF]

, 2012
Incorporation of cleavable linkers into peptides and proteins is of particular value in the study of biological processes. Here we describe the synthesis of a cleavable linker that is hypersensitive to oxidative cleavage as the result of the periodate ...
Altman, Andersen, Barlow, Beppu, Buist, Celie, Chen, Chen, Clamp, Donohoe, Dückers, Evans, Geoghegan, Gutierrez, Kwong, Leriche, Madden, Nicolaou, Rodenko, Rodenko, Sagui, Soen, Stanković, Steinreiber, Steinreiber, Stepan, Stone, Toebes, Toebes   +28 more
core   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy [PDF]

, 2015
Structural analysis of protein fibrillation is inherently challenging. Given the crucial role of fibrils in amyloid diseases, method advancement is urgently needed.
Annette E. Langkilde, Balbirnie, Bente Vestergaard, Berryman, Berryman, Blanchet, Cecchi, Collins, Debelouchina, Diaz-Avalos, Dmitri I. Svergun, Dunbrack, Eisenberg, Esposito, Fitzpatrick, Franke, Giehm, Gras, Jiménez, Kantardjieff, Knowles, Konarev, Kyle L. Morris, Langkilde, Langkilde, Lewandowski, Louise C. Serpell, Makin, Marshall, Morris, Narayanan, Nasica-Labouze, Nelson, Oliveira, Periole, Pettersen, Powers, Qi, Reches, Sawaya, Sikorski, Strodel, Stroud, Sunde, Svergun, Svergun, Vestergaard, Wel, Wel, Wickner, Wiltzius   +50 more
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source