Results 61 to 70 of about 2,268,571 (366)
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Prediction of Hemolysis Tendency of Peptides using a Reliable Evaluation Method [PDF]
arXiv, 2020 There are numerous peptides discovered through past decades, which exhibit antimicrobial and anti-cancerous tendencies. Due to these reasons, peptides are supposed to be sound therapeutic candidates. Some peptides can pose low metabolic stability, high toxicity and high hemolity of peptides.
arxiv
Docking Peptides into HIV/FIV Protease with Deep Learning and Focused Peptide Docking Methods [PDF]
arXiv, 2023 Molecular docking is a structure-based computational drug design technique for predicting the interaction between a small molecule (ligand) and a macromolecule (receptor). Over the past three decades various docking software programs have been developed, mostly for drug-like molecules.
arxiv
Zeitschrift für Kristallographie - New Crystal Structures, 2017 C68H72O10, triclinic, P1̅ (no. 2), a = 13.3619(4) Å, b = 13.9234(4) Å, c = 16.6975(5) Å, α = 96.023(2)°, β = 104.537(1)°, γ = 105.625(1)°, V = 2845.85(15) Å3, Z = 2, Rgt(F) = 0.0491, wRref(F2) = 0.1311, T = 173 K.
Samipillai Marivel +3 more
doaj +1 more source
The emergence of peptides in the pharmaceutical business: From exploration to exploitation
EuPA Open Proteomics, 2014 This minireview touches upon the challenges and opportunities peptides experience on the track to become an approved pharmaceutical. Peptide attributes originally considered troublesome with respect to drug development may now turn out to be more ...
Thomas Uhlig +7 more
doaj +1 more source
C-peptide: a predictor of cardiovascular mortality in subjects with established atherosclerotic disease [PDF]
, 2017 Aim: Insulin resistance and type 2 diabetes are independent risk factors for cardiovascular diseases. Levels of C-peptide are increased in these patients and its role in the atherosclerosis progression was studied in vitro and in vivo over the past ...
Ballanti, Marta +13 more
core +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Synthesis of Functionalized Dihydropyrido[2,3-d]pyrimidines in Aqueous Medium
SynOpen, 2018 Synthesis of functionalized 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one from a cascade reaction between 3-formylchromone, malononitrile, diammonium hydrogen phosphate, and aromatic aldehydes in aqueous media is described.
Saeed Balalaie +5 more
doaj +1 more source
Peptide-Gold Nanoparticle Conjugates as Artificial Carbonic Anhydrase Mimics [PDF]
, 2019 We herein describe the design and synthesis of a catalytically active peptide–gold nanoparticle conjugate (Pep-Au-NP) that binds Zn(II) within its peptide monolayer and develops carbonic anhydrase activity. Specifically, a modified variant of the β-sheet
Koksch, Beate, Mikolajczak, Dorian J.
core +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source