Results 61 to 70 of about 2,341,910 (347)
Evolutionary interplay between viruses and R‐loops
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi+4 more
wiley +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt+8 more
wiley +1 more source
The PIPS special issue features sixteen original research articles and four review articles. This issue gives a healthy slice of the science presented and inspired by the PIPS meeting as it pays homage to the pioneers, who participated at the meeting. The scientific rapport, festive environment, and educational content of this meeting in Paris inspired
Papini, Anna M. aria+2 more
openaire +3 more sources
Circulating histones as clinical biomarkers in critically ill conditions
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez+17 more
wiley +1 more source
An antitumor peptide RS17‐targeted CD47, design, synthesis, and antitumor activity
Background CD47 is a widely expressed transmembrane protein located on the surface of somatic cells. It mediates a variety of cellular processes including apoptosis, proliferation, adhesion, and migration.
Xinmin Wang+3 more
doaj +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi+3 more
wiley +1 more source
C16H20N2O4S, monoclinic, P21/n (no. 14), a = 9.229(2) Å, b = 16.995(4) Å, c = 11.084(3) Å, β = 99.985(11)°, V = 1712.3(8) Å3, Z = 4, Rgt(F) = 0.0393, wRref(F2) = 0.1081, T = 173.
Bhatt Nilay+5 more
doaj +1 more source
Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors
The potential for adoptive cell immunotherapy as a treatment against cancers has been demonstrated by the remarkable response in some patients with hematological malignancies using autologous T cells endowed with chimeric antigen receptors (CARs ...
Erhao Zhang, Jieyi Gu, Hanmei Xu
doaj +1 more source
Candidalysin is a fungal peptide toxin critical for mucosal infection
Cytolytic proteins and peptide toxins are classical virulence factors of several bacterial pathogens which disrupt epithelial barrier function, damage cells and activate or modulate host immune responses.
D. Moyes+29 more
semanticscholar +1 more source
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen+13 more
wiley +1 more source