Results 71 to 80 of about 3,746,064 (390)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

Nature Communications, 2018
Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome. Although the translation of circRNAs was reported, additional coding circRNAs and the functions of their translated products remain elusive.
Maolei Zhang, Kun Zhao, Xiaoping Xu, Yibing Yang, Sheng Yan, P. Wei, Hui Liu, Jianbo Xu, Feizhe Xiao, Huangkai Zhou, Xuesong Yang, Nunu Huang, Jinglei Liu, Kejun He, K. Xie, Gong Zhang, Suyun Huang, Nu Zhang   +17 more
semanticscholar   +1 more source

Solution structure of a bacterial microcompartment targeting peptide and its application in the construction of an ethanol bioreactor [PDF]

, 2014
Targeting of proteins to bacterial microcompartments (BMCs) is mediated by an 18-amino-acid peptide sequence. Herein, we report the solution structure of the N-terminal targeting peptide (P18) of PduP, the aldehyde dehydrogenase associated with the 1,2 ...
Brown, Ian R., Frank, Stefanie, Howard, Mark J., Lawrence, Andrew D., Lee, Matthew J., Mulvihill, Daniel P., Newnham, Sarah, Prentice, Michael B., Rowe, Michelle L., Warren, Martin J., Xue, Wei-Feng   +10 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

HPEPDOCK: a web server for blind peptide–protein docking based on a hierarchical algorithm

Nucleic Acids Res., 2018
Protein–peptide interactions are crucial in many cellular functions. Therefore, determining the structure of protein–peptide complexes is important for understanding the molecular mechanism of related biological processes and developing peptide drugs ...
Pei-Zhang Zhou, Bowen Jin, Hao Li, Shengyou Huang   +3 more
semanticscholar   +1 more source

Transcription of Brain Natriuretic Peptide and Atria1 Natriuretic Peptide Genes in Human Tissues. [PDF]

, 1994
We have compared the expression of atria1 natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes in various human tissues using a quantitative polymerase chain reaction technique.
Dagnino, Lina, Gerbes, Alexander L., Nemer, Mona, Nguyen, Than   +3 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver*

Journal of Biological Chemistry, 2001
Cysteine-rich antimicrobial peptides are abundant in animal and plant tissues involved in host defense. In insects, most are synthesized in the fat body, an organ analogous to the liver of vertebrates.
Christina H. Park, E. Valore, A. Waring, T. Ganz   +3 more
semanticscholar   +1 more source

Fibrin association at hybrid biointerfaces made of clot-binding peptides and polythiophene [PDF]

, 2016
The properties as biointerfaces of electroactive conducting polymer-peptide biocomposites formed by poly(3,4-ethylenedioxythiophene) (PEDOT) and CREKA or CR(NMe)EKA peptide sequences (where Glu has been replaced by N-methyl-Glu in the latter) have been ...
Agemy, Aradilla, Bhattacharyya, Blombäk, Boccaccio, Carr, Coelho, del Valle, Dolatshahi-Pirouz, Doolittle, Doolittle, Fabregat, Fabregat, Flamia, Groenendaal, Groenendaal, Gunawan, Guo, Hamedi, Hamzah, Han, Hoffman, Huang, Kirchmeyer, Li, Longa, López-Pérez, Maione, O'Brien, Oss, Pasqualini, Peters, Pérez-Madrigal, Pérez-Madrigal, Romero, She, Shi, Simberg, Soto-Delgado, Stevens, Wasilewska, Weisel, Weisel, Wong, Wu, Yuan, Zanuy, Zanuy, Zanuy, Zanuy, Zavyalova   +50 more
core   +4 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source