Results 91 to 100 of about 5,767,756 (178)

Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats

Experimental Physiology, EarlyView.
Abstract Loss of ovarian hormones (i.e., menopause) leads to negative effects on metabolic health. While exercise offers significant benefits, it seems to be insufficient to completely reverse these changes. The mechanisms by which exercise conveys the effects throughout the body are still poorly understood.
Veera Puumalainen, Anni Maja, Tia‐Marje Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira Karvinen   +7 more
wiley   +1 more source

Gene targeting using Peptide Nucleic Acid

, 2004
A brief overview of the properties of the deoxyribonucleic acid mimic peptide nucleic acid (PNA) is given, and the recent progress in cellular delivery of PNA and of using PNA oligomers for antisense and antigene gene targeting is ...
Nielsen, Peter E.
core   +1 more source

The combination of morphogenic regulators BABY BOOM and GRF‐GIF improves maize transformation efficiency and promotes leaf regeneration

New Phytologist, Volume 252, Issue 1, Page 260-275, October 2026.
Maize regeneration via somatic embryogenesis by ectopic expression of morphogenic factors TaGRF4‐TaGIF1 and ZmBBM. Summary Transformation is an indispensable tool for plant genetics and functional genomics. Although stable transformation in maize is no longer a major obstacle, there remains a need for accessible and efficient methods for academic ...
Zongliang Chen, Jiaqi Zhou, Mary Galli, Sessen Daniel Iohannes, Theresa Clark, Juan M. Debernardi, Jorge Dubcovsky, David Jackson, Andrea Gallavotti   +8 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, Volume 600, Issue 17, Page 2579-2614, September 2026.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

Artificial intelligence driven diet‐intestinal microbiota‐host health integration: A four‐dimensional paradigm for advancing host wellness research

iMetaOmics, Volume 3, Issue 3, September 2026.
This graphical abstract presents a novel Diet‐Artificial Intelligence (AI)‐intestinal Microbiota–Host Health paradigm integrating microbiota‐centric pathways and an AI‐driven multi‐omics workflow. Diet shapes gut bacteria that regulate intestinal mucosal integrity, immune signaling, and gut–brain neurotransmitters to influence host health.
Tianle He, Shuobo Zhang, Jiaxin Chen, Xiaoling Zheng, Jixin Zhao, Huifeng Li, Jiani Mao, Ju Luo, Jundan Zheng, Dengjun Ma, Lihong Wang, Junhui Liu, Wen Tian, Shuangming Yang, Chengli Liu, Ke Tian, Zhenguo Yang   +16 more
wiley   +1 more source

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, Volume 2, Issue 3, September 2026.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

Natural Product‐Derived Vesicles in Nanotherapeutics

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Natural product‐derived vesicles (NPVs) are an emerging nature‐based nanotherapeutic that can deliver bioactive metabolites into the target site and induce beneficial mechanisms. A practical, chronological bench‐to‐bedside approach throughout the entire NPV development process is expected to resolve challenges encountered in NPV studies.
Kartiko Arif Purnomo, Tsong‐Long Hwang
wiley   +1 more source

Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti‐Inflammatory Effects but Upregulates HO‐1 and Alters Adiponectin Levels in Human Adipocytes

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro.
Johanna Matilainen, Sanni Foster, Viivi Berg, Janne Tampio, Tanja Turunen, Anne‐Mari Mustonen, Heikki Kyykallio, Maija Vaittinen, Ville Männistö, Jussi Pihlajamäki, Marjo Malinen, Sanna Oikari, Pirjo Käkelä, Dorota Kaminska, Veera Luukkonen, Kristiina M. Huttunen, Martin Wabitsch, Petteri Nieminen, Kirsi Rilla   +18 more
wiley   +1 more source