Results 41 to 50 of about 82,531 (244)

Using high-abundance proteins as guides for fast and effective peptide/protein identification from human gut metaproteomic data

Microbiome, 2021
Background A few recent large efforts significantly expanded the collection of human-associated bacterial genomes, which now contains thousands of entities including reference complete/draft genomes and metagenome assembled genomes (MAGs).
Moses Stamboulian, Sujun Li, Yuzhen Ye
doaj   +1 more source

Protein charge distribution in proteomes and its impact on translation. [PDF]

PLoS Computational Biology, 2017
As proteins are synthesized, the nascent polypeptide must pass through a negatively charged exit tunnel. During this stage, positively charged stretches can interact with the ribosome walls and slow the translation. Therefore, charged polypeptides may be
Rodrigo D Requião, Luiza Fernandes, Henrique José Araujo de Souza, Silvana Rossetto, Tatiana Domitrovic, Fernando L Palhano   +5 more
doaj   +1 more source

Reversing the relative time courses of the peptide bond reaction with oligopeptides of different lengths and charged amino acid distributions in the ribosome exit tunnel

Computational and Structural Biotechnology Journal
The kinetics of the protein elongation cycle by the ribosome depends on intertwined factors. One of these factors is the electrostatic interaction of the nascent protein with the ribosome exit tunnel.
Marc Joiret, Frederic Kerff, Francesca Rapino, Pierre Close, Liesbet Geris   +4 more
doaj   +1 more source

Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity

BMC Plant Biology, 2008
Background Latest research shows that small antimicrobial peptides play a role in the innate defense system of plants. These peptides typically contribute to preformed defense by developing protective barriers around germinating seeds or between ...
Vivier Melané A, de Beer Abré
doaj   +1 more source

Complex Formation of the Elongation Factor Tu from Pseudomonas aeruginosa with Nucleoside Diphosphate Kinase Modulates Ribosomal GTP Synthesis and Peptide Chain Elongation [PDF]

Journal of Biological Chemistry, 1997
The elongation factor Tu (EF-Tu) from Pseudomonas aeruginosa was purified as a 45-kDa polypeptide that forms a complex with both the 12- and 16-kDa forms of nucleoside-diphosphate kinase (Ndk) and predominantly synthesizes GTP. 70 S ribosomes of P. aeruginosa predominantly synthesize GTP, which is inhibited in presence of anti-Ndk antibodies.
S, Mukhopadhyay, S, Shankar, W, Walden, A M, Chakrabarty   +3 more
openaire   +2 more sources

The role of molecular chaperone CCT/TRiC in translation elongation: A literature review

Heliyon
Protein synthesis from mRNA is an energy-intensive and strictly controlled biological process. Translation elongation is a well-coordinated and multifactorial step in translation that ensures the accurate and efficient addition of amino acids to a ...
Yueyue Que, Yudan Qiu, Zheyu Ding, Shanshan Zhang, Rong Wei, Jianing Xia, Yingying Lin   +6 more
doaj   +1 more source

Divergent effects of fluoroaluminates on the peptide chain elongation factors EF‐Tu and EF‐G as members of the GTPase superfamily [PDF]

FEBS Letters, 1993
Fluoroaluminates are thought to mimic the γ‐phosphate of GTP and thus, together with GDP, perturb the functioning of heterotrimeric GTP‐binding G‐proteins. Here we show they do inhibit the ribosome‐stimulated GTPase activity of EF‐G from Escherichia coli via the formation of a stable complex with EF‐G·GDP and ribosomes.
Mesters, Jeroen R., de Graaf, J.Martien, Kraal, Barend   +2 more
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

The gene YEF3 function encoding translation elongation factor eEF3 is partially conserved across fungi

Frontiers in Microbiology
IntroductionTranslation is a fundamental process of life. In eukaryotes, the elongation step of translation is highly conserved and is driven by eukaryotic translation elongation factors (eEF)1A and eEF2.
Giovanna Maldonado, Alejandra García, Saturnino Herrero, Irene Castaño, Michael Altmann, Reinhard Fischer, Greco Hernández, Greco Hernández   +7 more
doaj   +1 more source

Role of peptide chain elongation factor G in guanosine 5'-diphosphate 3'-diphosphate synthesis. [PDF]

Journal of Bacteriology, 1981
In a wild-type strain (relA+) of Escherichia coli, starvation of amino acid led to an immediate cessation of the synthesis of stable ribonucleic acids, together with the accumulation of an unusual nucleotide, guanosine 5'-diphosphate 3'-diphosphate, commonly known as ppGpp. This compound also accumulated during heat shock.
C C, Pao, J, Fleckenstein, B T, Dyess
openaire   +2 more sources