Results 41 to 50 of about 159,783 (279)

Protein charge distribution in proteomes and its impact on translation. [PDF]

PLoS Computational Biology, 2017
As proteins are synthesized, the nascent polypeptide must pass through a negatively charged exit tunnel. During this stage, positively charged stretches can interact with the ribosome walls and slow the translation. Therefore, charged polypeptides may be
Rodrigo D Requião, Luiza Fernandes, Henrique José Araujo de Souza, Silvana Rossetto, Tatiana Domitrovic, Fernando L Palhano   +5 more
doaj   +1 more source

The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy [PDF]

, 2015
Structural analysis of protein fibrillation is inherently challenging. Given the crucial role of fibrils in amyloid diseases, method advancement is urgently needed.
Annette E. Langkilde, Balbirnie, Bente Vestergaard, Berryman, Berryman, Blanchet, Cecchi, Collins, Debelouchina, Diaz-Avalos, Dmitri I. Svergun, Dunbrack, Eisenberg, Esposito, Fitzpatrick, Franke, Giehm, Gras, Jiménez, Kantardjieff, Knowles, Konarev, Kyle L. Morris, Langkilde, Langkilde, Lewandowski, Louise C. Serpell, Makin, Marshall, Morris, Narayanan, Nasica-Labouze, Nelson, Oliveira, Periole, Pettersen, Powers, Qi, Reches, Sawaya, Sikorski, Strodel, Stroud, Sunde, Svergun, Svergun, Vestergaard, Wel, Wel, Wickner, Wiltzius   +50 more
core   +1 more source

Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]

, 2019
During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R., Bock, L., Grubmüller, H., Peng, B., Peske, F., Rodnina, M.   +5 more
core   +2 more sources

Complex Formation of the Elongation Factor Tu from Pseudomonas aeruginosa with Nucleoside Diphosphate Kinase Modulates Ribosomal GTP Synthesis and Peptide Chain Elongation [PDF]

Journal of Biological Chemistry, 1997
The elongation factor Tu (EF-Tu) from Pseudomonas aeruginosa was purified as a 45-kDa polypeptide that forms a complex with both the 12- and 16-kDa forms of nucleoside-diphosphate kinase (Ndk) and predominantly synthesizes GTP. 70 S ribosomes of P. aeruginosa predominantly synthesize GTP, which is inhibited in presence of anti-Ndk antibodies.
S, Mukhopadhyay, S, Shankar, W, Walden, A M, Chakrabarty   +3 more
openaire   +2 more sources

The Peach RGF/GLV Signaling Peptide pCTG134 Is Involved in a Regulatory Circuit That Sustains Auxin and Ethylene Actions [PDF]

, 2017
In vascular plants the cell-to-cell interactions coordinating morphogenetic and physiological processes are mediated, among others, by the action of hormones, among which also short mobile peptides were recognized to have roles as signals.
Dale F. Mierke, Fabrizio Costa, Francesca Resentini, Livio Trainotti, Lorella Navazio, Maria Pellegrini, Nicola Busatto, Nicola Busatto, Oriano Marin, Silvia Quaresimin, Umberto Salvagnin   +10 more
core   +3 more sources

Role of peptide chain elongation factor G in guanosine 5'-diphosphate 3'-diphosphate synthesis. [PDF]

Journal of Bacteriology, 1981
In a wild-type strain (relA+) of Escherichia coli, starvation of amino acid led to an immediate cessation of the synthesis of stable ribonucleic acids, together with the accumulation of an unusual nucleotide, guanosine 5'-diphosphate 3'-diphosphate, commonly known as ppGpp. This compound also accumulated during heat shock.
C C, Pao, J, Fleckenstein, B T, Dyess
openaire   +2 more sources

Reversing the relative time courses of the peptide bond reaction with oligopeptides of different lengths and charged amino acid distributions in the ribosome exit tunnel

Computational and Structural Biotechnology Journal
The kinetics of the protein elongation cycle by the ribosome depends on intertwined factors. One of these factors is the electrostatic interaction of the nascent protein with the ribosome exit tunnel.
Marc Joiret, Frederic Kerff, Francesca Rapino, Pierre Close, Liesbet Geris   +4 more
doaj   +1 more source

Ricin trafficking in plant and mammalian cells [PDF]

, 2011
Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A.
core   +2 more sources

Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity

BMC Plant Biology, 2008
Background Latest research shows that small antimicrobial peptides play a role in the innate defense system of plants. These peptides typically contribute to preformed defense by developing protective barriers around germinating seeds or between ...
Vivier Melané A, de Beer Abré
doaj   +1 more source

Molecular Simulations of the Ribosome and Associated Translation Factors

, 2014
The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information.
Hamed H. Alsulami (532535), Muhammad Bilal Ashraf (532534), Muhammad Shahab Alhuthali (532536), Tasawar Hayat (433317)   +3 more
core   +6 more sources