Results 31 to 40 of about 159,783 (279)

Cotranslational folding of proteins on the ribosome.

, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]

, 2013
The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem, A Devaraj, AA Malygin, AD Petropoulos, AY Keel, Breanna S Vollmar, C Chen, CM Spahn, CS Fraser, CS Fraser, D Boehringer, D Hartz, D Sousa, Dan Shi, DD Ian'shina, DV Sizova, EF Pettersen, F Odreman-Macchioli, F Peske, F Robert, GA Otto, GJ Kleywegt, H Ji, IB Lomakin, IM Terenin, J Bukh, J Rabl, J Wower, JA Mindell, JE Wilson, Jeffrey S Kieft, JH Kim, JM Fringer, JR Lytle, JR Lytle, JS Kieft, JS Kieft, K Tsukiyama-Kohara, KE Berry, KI Kalliampakou, LA Passmore, M Honda, M Ohi, M Selmer, M Stoneley, M van Heel, ME Filbin, Megan E Filbin, MG Acker, MM Yusupov, N Grigorieff, N Locker, O Galkin, P Antúnez de Mayolo, P Simmonds, PJ Lukavsky, PJ Lukavsky, RE Monro, RJ Jackson, S Fukushi, S Uemura, SM Dibrov, T Döring, Tamir Gonen, TV Pestova, TV Pestova, U Geigenmüller, VG Kolupaeva, Y Yu   +68 more
core   +1 more source

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]

, 2015
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D, Jain, Rishi K, Merrick, William C, Miller, Howard R, Ross, Nathan T, Sethofer, Steven G, Simard, Jillian L, Smith, Geoffrey A, Taunton, Jack   +8 more
core   +2 more sources

Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli

mBio, 2017
In vitro assays find that ribosomes form peptide bonds to proline (Pro) residues more slowly than to other residues. Ribosome profiling shows that stalling at Pro-Pro-X triplets is especially severe but is largely alleviated in Escherichia coli by the ...
Sonisilpa Mohapatra, Heejun Choi, Xueliang Ge, Suparna Sanyal, James C. Weisshaar   +4 more
doaj   +1 more source

Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease

Cancer Cell International, 2020
The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the function of these two proteins.
Gao-Qi Wu, Yan-Ming Xu, Andy T. Y. Lau
doaj   +1 more source

Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases. [PDF]

PLoS ONE, 2011
Legionella pneumophila, which is the causative organism of Legionnaireś disease, translocates numerous effector proteins into the host cell cytosol by a type IV secretion system during infection.
Tina Tzivelekidis, Thomas Jank, Corinna Pohl, Andreas Schlosser, Sabine Rospert, Charlotte R Knudsen, Marina V Rodnina, Yury Belyi, Klaus Aktories   +8 more
doaj   +1 more source

Microbial Proteins in Stomach Biopsies Associated with Gastritis, Ulcer, and Gastric Cancer

Molecules, 2022
(1) Background: Gastric cancer (GC) is the fourth leading cause of cancer-related deaths worldwide. Helicobacter pylori infection is a major risk factor, but other microbial species may also be involved.
Shahid Aziz, Faisal Rasheed, Tayyab Saeed Akhter, Rabaab Zahra, Simone König   +4 more
doaj   +1 more source

Insight Into Pituitary lncRNA and mRNA at Two Estrous Stages in Small Tail Han Sheep With Different FecB Genotypes

Frontiers in Endocrinology, 2022
The pituitary is a remarkably dynamic organ with roles in hormone (FSH and LH) synthesis and secretion. In animals with the FecB (fecundity Booroola) mutation, the pituitary experiences hormone fluctuations during the follicular–luteal transition, which ...
Si Chen, Xiaofei Guo, Xiaofei Guo, Xiaoyun He, Ran Di, Xiaosheng Zhang, Jinlong Zhang, Xiangyu Wang, Mingxing Chu   +8 more
doaj   +1 more source

Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]

, 2017
In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M, Conn, Adam B, Diggs, Stephen, Fan, Haitian, Gamper, Howard B, Hahm, Joseph, Hou, Ya-Ming, O'Leary, Seán E, Wang, Yinsheng, Williams, Preston B   +9 more
core   +1 more source

Using high-abundance proteins as guides for fast and effective peptide/protein identification from human gut metaproteomic data

Microbiome, 2021
Background A few recent large efforts significantly expanded the collection of human-associated bacterial genomes, which now contains thousands of entities including reference complete/draft genomes and metagenome assembled genomes (MAGs).
Moses Stamboulian, Sujun Li, Yuzhen Ye
doaj   +1 more source