Results 221 to 230 of about 30,187 (256)

Antimicrobial d-Peptide Hydrogels

ACS Biomaterials Science & Engineering, 2021
Biofilms are widely involved in human lives, such as in medical infection, environmental remediation, and industrial processes. However, the control of the biofilm has still been a challenge because of its strong drug resistance. Here, we designed and synthesized an amphipathic antimicrobial peptide (Ac-DKDHDHDQDKDLDVDFDFDADK-NH2 (KKd-11)) that was ...
Zhen Guo, Yujiao Wang, Tingyuan Tan, Yuwen Ji, Jun Hu, Yi Zhang   +5 more
openaire   +2 more sources

Self-healing cyclic peptide hydrogels

Journal of Materials Chemistry B, 2023
The structural design principles of cyclic peptides-based hydrogels are introduced. The resulting soft materials exhibited self-healing capabilities.
Alfonso Bayón-Fernández, Alejandro Méndez-Ardoy, Carmen Alvarez-Lorenzo, Juan R. Granja, Javier Montenegro   +4 more
openaire   +2 more sources

Peptide‐based hydrogels as delivery systems for doxorubicin

Journal of Peptide Science, 2021
Hydrogels (HGs) and nanogels (NGs) have been recently identified as innovative supramolecular materials for many applications in biomedical field such as in tissue engineering, optoelectronic, and local delivery of active pharmaceutical ingredients (APIs).
Carlo Diaferia, Elisabetta Rosa, Antonella Accardo, Giancarlo Morelli   +3 more
openaire   +3 more sources

Peptide hydrogels: mimicking the extracellular matrix

Bioinspired, Biomimetic and Nanobiomaterials, 2012
The extracellular matrix (ECM) is a complex and dynamic three-dimensional (3D) environment consisting largely of a variety of collagenous and non-collagenous fibres, non-fibrous proteins and proteoglycans. Other components often overlooked include various growth factors and other signalling molecules which can diffuse through and bind to various ...
Gough, JE; id_orcid 0000-0002-1270-0616, Saiani, A; id_orcid 0000-0002-5504-8306, Miller, AF; id_orcid 0000-0003-2731-3536   +2 more
openaire   +1 more source

Branched peptides for enzymatic supramolecular hydrogelation

Chemical Communications, 2018
The use of protease ( e.g. , enterokinase) to cut branched peptides generates supramolecular hydrogels, opening a new way to explore soft materials for biomedicine.
Hongjian He, Huaimin Wang, Ning Zhou, Dongsik Yang, Bing Xu   +4 more
openaire   +2 more sources

Multifunctional thermoresponsive designer peptide hydrogels

Acta Biomaterialia, 2017
We report the synthesis and characterization of multifunctional peptides comprised of a hydrogel forming β-sheet peptide segment and a matrix metalloproteinase 2 substrate containing a propargylglycinyl linker that is further derivatized with an RGD peptide sequence via "click" chemistry.
Luis M, De Leon-Rodriguez, Yacine, Hemar, Guang, Mo, Alok K, Mitra, Jillian, Cornish, Margaret A, Brimble   +5 more
openaire   +2 more sources

Mechanics of single peptide hydrogelator fibrils

Nanoscale, 2015
The rigidity of peptide fibers is essential for their chemical and biological functions, despite that it remains largely unexplored.
Ying, Li, Yang, Sun, Meng, Qin, Yi, Cao, Wei, Wang   +4 more
openaire   +2 more sources

Membrane-Disrupting Nanofibrous Peptide Hydrogels

ACS Biomaterials Science & Engineering, 2019
Self-assembled peptide nanofibers can form biomimetic hydrogels at physiological pH and ionic strength through noncovalent and reversible interactions. Inspired by natural antimicrobial peptides, we designed a class of cationic amphiphilic self-assembled peptides (CASPs) that self-assemble into thixotropic nanofibrous hydrogels. These constructs employ
Biplab Sarkar, Zain Siddiqui, Peter K. Nguyen, Namita Dube, Wanyi Fu, Steven Park, Shivani Jaisinghani, Reshma Paul, Stephen D. Kozuch, Daiyong Deng, Patricia Iglesias-Montoro, Mengyan Li, David Sabatino, David S. Perlin, Wen Zhang, Jagannath Mondal, Vivek A. Kumar   +16 more
openaire   +2 more sources

Hybrid Peptide–Agarose Hydrogels for 3D Immunoassays

2022
Recent advances in biosensing analytical platforms have brought relevant outcomes for novel diagnostic and therapy-oriented applications. In this context, 3D droplet microarrays, where hydrogels are used as matrices to stably entrap biomolecules onto analytical surfaces, potentially provide relevant advantages over conventional 2D assays, such as ...
Angelo Musicò, Greta Bergamaschi, Alessandro Strada, Roberto Frigerio, Paola Gagni, Marina Cretich, Alessandro Gori   +6 more
openaire   +4 more sources

Short peptide based hydrogels: incorporation of graphene into the hydrogel

Soft Matter, 2011
Stable supramolecular hydrogels were obtained from Fmoc (N-fluorenyl-9-methoxycarbonyl) protected synthetic dipeptides, Fmoc-Xaa-Asp-OH (Xaa = Tyr, Phe). These hydrogels were characterized by various methods including transmission electron microscopy (TEM), field-emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM ...
Bimalendu Adhikari, Arindam Banerjee
openaire   +1 more source