Results 111 to 120 of about 33,588 (318)
Hotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension [PDF]
arXivPeptides, short chains of amino acids, interact with target proteins, making them a unique class of protein-based therapeutics for treating human diseases. Recently, deep generative models have shown great promise in peptide generation. However, several challenges remain in designing effective peptide binders. First, not all residues contribute equally
arxiv
Peptide hydrolase activity of human intestinal mucosa in adult coeliac disease [PDF]
, 1970 Adrian P. Douglas, T. J. Peters
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Chemistry – A European Journal, EarlyView.Development of highly stable bionanocomposite dispersions of antioxidant and protease activities was achieved by co‐immobilization of TA and papain on LDH nanoparticles. Abstract The synchronized operation of antioxidants and enzymes is necessary for the proper functioning of living organisms and various industrial processes.
Zsuzsanna D. Konya +2 more
wiley +1 more source
Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres
Marine Drugs, 2017 Tachyplesin I is a cationic peptide isolated from hemocytes of the horseshoe crab and its anti-tumor activity has been demonstrated in several tumor cells. However, there is limited information providing the global effects and mechanisms of tachyplesin I
Xuan Li +4 more
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Partial Purification and Characterization of Two Peptide Hydrolases from Pea Seeds [PDF]
, 1976 J. Bruce Caldwell, Lindsay G. Sparrow
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Chemistry – A European Journal, EarlyView.We designed and synthesized novel mannose‐6‐phosphate (M6P) derivatives to enhance their binding affinity for the CI‐M6P/IGF2 receptor, which plays a key role in lysosomal targeting. Using a fluorescence polarization assay, we evaluated di‐, tri‐, and penta‐M6P peptides and modified M6P analogs.
Lucie Mrázková +11 more
wiley +1 more source
Shotgun proteomic analysis of Anaeroglobus geminatus
Journal of Oral Microbiology, 2017 Objectives: Anaeroglobus geminatus is a gram-negative species belonging to the family of Veillonellaceae and close associate to genus Megasphaera. The role of the species within dysbiotic microbial communities is not yet clear.
Kai Bao +3 more
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Clinical Pharmacology &Therapeutics, EarlyView.Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann +6 more
wiley +1 more source
Scientific Reports, 2017 Understanding the molecular mechanisms of bacterial antibiotic resistance will help prepare against further emergence of multi-drug resistant strains. MacQ is an enzyme responsible for the multi-drug resistance of Acidovorax sp. strain MR-S7.
Yoshiaki Yasutake +6 more
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ChemSusChem, Accepted Article.Hydroxylated derivatives of arachidonic acid play crucial roles in physiology and inflammation response, with distinct biological effects for (R)‐ and (S)‐enantiomers, highlighting their pharmaceutical relevance. Here, we harness recombinant unspecific peroxygenases (UPOs)—from the fungi Coprinopsis cinerea (rCciUPO) and Agrocybe aegerita (rAaeUPO ...
Alejandro González-Benjumea +7 more
wiley +1 more source