Results 1 to 10 of about 362,038 (188)

Continuation, Resumption, and Withdrawal Rates of CGRP-mAb Treatment for Migraine Under Real-World Clinical Conditions in Which Patients Are Free to Choose Own Treatment [PDF]

Neurology International
Background/Objectives: Anti-calcitonin gene-related peptide monoclonal antibodies (CGRP-mAbs) are effective injectable medications for the treatment of migraine.
Takafumi Tanei, Satoshi Yamashita, Satoshi Maesawa, Yusuke Nishimura, Tomotaka Ishizaki, Yoshitaka Nagashima, Takahiro Suzuki, Hajime Hamasaki, Shun Yamamoto, Toshihiko Wakabayashi, Ryuta Saito   +10 more
doaj   +2 more sources

A rationally designed antimicrobial peptide from structural and functional insights of Clostridioides difficile translation initiation factor 1

Microbiology Spectrum
A significant increase of hospital-acquired bacterial infections during the COVID-19 pandemic has become an urgent medical problem. Clostridioides difficile is an urgent antibiotic-resistant bacterial pathogen and a leading causative agent of nosocomial ...
Elvira Alanis, Faith Aguilar, Niaz Banaei, Frank B. Dean, Alexa Villarreal, Miguel Alanis, Karen Lozano, James M. Bullard, Yonghong Zhang   +8 more
doaj   +3 more sources

Peptide antibody tools to dissect specific functions of eIF4A paralogs in cancer [PDF]

Discover Oncology
Eukaryotic translation initiation factors (eIFs) are key regulators of messenger RNA (mRNA) translation, a process highly dysregulated in cancer. Among these paralogs, eIF4A1 and eIF4A2 are closely related DEAD box mRNA helicases that, despite their high
Shobhit Srivastava, Azeezat Osikoya, David Terrero, Dayanidhi Raman   +3 more
doaj   +2 more sources

Elucidation of the Translation Initiation Factor Interaction Network of Haloferax volcanii Reveals Coupling of Transcription and Translation in Haloarchaea

Frontiers in Microbiology, 2021
Translation is an important step in gene expression. Initiation of translation is rate-limiting, and it is phylogenetically more diverse than elongation or termination. Bacteria contain only three initiation factors. In stark contrast, eukaryotes contain
Franziska Schramm, Andreas Borst, Uwe Linne, Jörg Soppa   +3 more
doaj   +1 more source

Cholesteryl esters are bound by a peptide-initiation and a peptide-elongation factor [PDF]

Biochemical Journal, 1980
Significantly higher quantities of cholesteryl 14-methylhexadecanoate than of cholesteryl laurate and cholesteryl palmitate are bound by a homogeneous peptide-initiation factor and purified peptide-elongation factor 1. Cholesteryl 14-methylhexadecanoate may function as a specific allosteric modifier changing the conformation of protein synthesis ...
Z, Tuhácková, J, Hradec
openaire   +2 more sources

RALFL34 regulates formative cell divisions in Arabidopsis pericycle during lateral root initiation [PDF]

, 2016
We describe the role of RALFL34 during early events in lateral root development, and demonstrate its specific importance in orchestrating formative cell divisions in the pericycle.In plants, many signalling molecules, such as phytohormones, miRNAs ...
Beeckman, Tom, Brady, Siobhan M, De Smet, Ive, Fukaki, Hidehiro, Gaudinier, Allison, Goh, Tatsuaki, Inzé, Dirk, Lin, Zhefeng, Murphy, Evan, Ramakrishna, Priya, Slane, Daniel, Van De Cotte, Brigitte, Van den Broeck, Lisa, Vu, Lam Dai   +13 more
core   +7 more sources

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E [PDF]

Current Biology, 2000
Overexpression of the translation initiation factor eIF4E leads to cell transformation and occurs in a number of human cancers [1]. mRNA translation and cell growth can be regulated through the availability of eIF4E to form initiation complexes by binding to eIF4G. The availability of eIF4E is blocked through the binding of members of a family of eIF4E-
Herbert, Terence P., Fåhraeus, Robin, Prescott, Alan, Lane, David P., Proud, Chris G.   +4 more
openaire   +3 more sources

Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α [PDF]

Oxidative Medicine and Cellular Longevity, 2020
Alzheimer’s disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part mediated by free radicals. Interestingly, it has been reported that oxidative stress can
Pol Picón-Pagès, Daniela A. Gutiérrez, Alejandro Barranco-Almohalla, Giulia Crepin, Marta Tajes, Gerard ILL-Raga, Francesc X. Guix, Silvia Menéndez, Montserrat Arumí-Uría, Rubén Vicente, Alejandra R. Álvarez, Francisco J. Muñoz   +11 more
openaire   +4 more sources

Disparities in SGLT2 Inhibitor or Glucagon-Like Peptide 1 Receptor Agonist Initiation Among Medicare-Insured Adults With CKD in the United StatesPlain-Language Summary

Kidney Medicine, 2023
Rationale & Objective: Information regarding disparities in initiating sodium/glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) in patients with chronic kidney disease (CKD) is limited.
Julie Z. Zhao, Eric D. Weinhandl, Angeline M. Carlson, Wendy L. St. Peter   +3 more
doaj   +1 more source

Puromycin-Peptide Bond Formation with Reticulocyte Initiation Factors M ₁ and M ₂ [PDF]

Proceedings of the National Academy of Sciences, 1971
The ability to form a “peptide” bond between various forms of Met-tRNA or Phe-tRNA and puromycin has been studied in the reticulocyte cell-free system. When Met-tRNA F , fMet-tRNA F , or N -acetylPhe-tRNA are used as substrate at low Mg ...
D A, Shafritz, D G, Laycock, W F, Anderson   +2 more
openaire   +2 more sources