BMC Biology, 2007 Background Upstream open reading frames (uORFs) can mediate translational control over the largest, or major ORF (mORF) in response to starvation, polyamine concentrations, and sucrose concentrations.
Jorgensen Richard A, Hayden Celine A
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Plasma N-Terminal Pro-Brain Natriuretic Peptide as Prognostic Marker in Fatal Cardial Decompensation with Sunitinib Malate Therapy [PDF]
, 2010 A 74-year-old man with metastatic renal cell carcinoma and a history of cardiac failure was treated with sunitinib malate. MUGA echocardiography could not detect a relevant change in the ejection fraction although the clinical situation of the patient ...
Haseke, Nicolas +4 more
core +1 more source
A biologically active peptide mimetic of N-acetylgalactosamine/galactose
BMC Research Notes, 2009 Background Glycosylated proteins and lipids are important regulatory factors whose functions can be altered by addition or removal of sugars to the glycan structure.
Hoober J Kenneth, Eggink Laura L
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The Journal of Headache and Pain, 2022 Background Fremanezumab, a fully humanized monoclonal antibody (mAb; IgG2Δa) that selectively targets calcitonin gene-related peptide (CGRP), is approved for the preventive treatment of migraine in adults.
Maurice T. Driessen +10 more
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Modulation of Arabidopsis and monocot root architecture by CLAVATA3/EMBRYO SURROUNDING REGION 26 peptide [PDF]
, 2015 Plant roots are important for a wide range of processes, including nutrient and water uptake, anchoring and mechanical support, storage functions, and as the major interface with the soil environment.
Brigitte Van +7 more
core +2 more sources
Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 and Eukaryotic Translation Initiation Factor 4G [PDF]
Journal of Medicinal Chemistry, 2019 Protein disorder plays a crucial role in signal transduction and is key for many cellular processes including transcription, translation, and cell cycle. Within the intrinsically disordered protein interactome, the α-helix is commonly used for binding, which is induced via a disorder-to-order transition.
Erin E. Gallagher +5 more
openaire +2 more sources
Molecular Plant-Microbe Interactions, 2000 A new strategy has been designed to identify putative pathogenicity factors from the dorsal or subventral esophageal glands of the potato cyst nematode Globodera rostochiensis. Three independent criteria were used for selection.
Ling Qin +9 more
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Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex [PDF]
, 1998 The Xenopus origin recognition complex is essential for chromosomal DNA replication in cell-free extracts. We have immunopurified the Xenopus origin recognition complex with anti-Xorc2 antibodies and analyzed its composition and properties.
Carpenter, Phillip B. +1 more
core +1 more source
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]
, 2012 Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas +47 more
core +4 more sources
159 Stapled-peptides targeting the protein-binding interface of eukaryotic Translation Initiation Factor 4E (eIF4E) protein [PDF]
Journal of Biomolecular Structure and Dynamics, 2015 Targeting undruggable protein-protein interacting sites has received a promising boost with the developments of an emerging class of peptidomimetics called stapled-peptides (Verdine & Hilinski, 201...
Dilraj Lama +4 more
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