Life, 2022 Tuberculosis (TB) remains one of the deadliest infectious diseases in the world. Although several established antitubercular drugs have been found, various factors obstruct efforts to combat this disease due to the existence of drug-resistance (DR) TB ...
Filia Stephanie +3 more
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Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]
, 2020 The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard +3 more
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RheumatologyIntroduction Identifying early predictive factors of how rheumatoid arthritis (RA) patients respond to rituximab (RTX) treatment is crucial for both individual treatment outcome and the improvement of clinical practice overall.
Evgenija Mihajloska +9 more
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Cardioprotective Strategies from Cardiotoxicity in Cancer Patients: A Comprehensive Review
Journal of Cardiovascular Development and Disease, 2022 Cardiotoxicity is a significant complication of chemotherapeutic agents in cancer patients. Cardiovascular incidents including LV dysfunction, heart failure (HF), severe arrhythmias, arterial hypertension, and death are associated with high morbidity and
Christos Kourek +6 more
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Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
, 2017 Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
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The KiSS-1/GPR54 system: Essential roles in physiological homeostasis and cancer biology
Genes and Diseases, 2022 KiSS-1, first identified as an anti-metastasis gene in melanoma, encodes C-terminally amidated peptide products, including kisspeptin-145, kisspeptin-54, kisspeptin-14, kisspeptin-13 and kisspeptin-10.
Nisha Zhu +4 more
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Molecular Simulations of the Ribosome and Associated Translation Factors
, 2014 The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information.
Hamed H. Alsulami (532535) +3 more
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The role of olefin geometry in the activity of hydrocarbon stapled peptides targeting eukaryotic translation initiation factor 4E (eIF4E) [PDF]
Organic & Biomolecular Chemistry, 2019 Ring-closing metathesis of monosubstituted alkenyl amino acids leads to stapled peptides with differing olefin geometry and biological activity.
James M. Song +4 more
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The chemotherapeutic agent bortezomib induces the formation of stress granules
Cancer Cell International, 2010 Background Cytoplasmic stress granules (SGs) are specialized storage sites of untranslated mRNAs whose formation occurs under different stress conditions and is often associated with cell survival. SGs-inducing stresses include radiations, hypoxia, viral
Gareau Cristina +2 more
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Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry [PDF]
, 2008 P pili are multisubunit fibers essential for the attachment of uropathogenic Escherichia coli to the kidney. These fibers are formed by the noncovalent assembly of six different homologous subunit types in an array that is strictly defined in terms of ...
A. E. Ashcroft +28 more
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