Results 201 to 210 of about 840,168 (263)

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Chirality Effect on Physical and Biological Properties of Peptide-Based Hydrogels. [PDF]

Gels
De Rosa L, D'Andrea LD, Romanelli A.
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Readability of AI-Generated Patient Information on Glucagon-Like Peptide-1 Receptor Agonists. [PDF]

JMIR Bioinform Biotechnol
Williams T, Bilic-Curcic I, Hurley J, Mummareddy H, Cigrovski Berkovic M, Canecki Varzic S, Gradiser M.   +6 more
europepmc   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Progress and Perspectives of Molecular Imprinting Methods in the Development of Electrochemical Protein Biosensors. [PDF]

Biosensors (Basel)
Yang S, Chang X, Liu L.
europepmc   +1 more source

Evaluating the remineralisation potential and clinical evidence of emerging biocompatible materials in restorative dentistry: a systematic review. [PDF]

Biomater Investig Dent
Isaiselvi D, Indumathi KP, Sibyl S, Krishnaprakash G.   +3 more
europepmc   +1 more source

MccB-catalyzed C-terminal Thioesterification for Protein Bioconjugation. [PDF]

Curr Protoc
Yang D, Weeks AM.
europepmc   +1 more source

The Effect of Aza-Glycine Substitution on the Internalization of Dabcyl-Containing Short Oligoarginine. [PDF]

Biomedicines
Tarchoun K, Soltész D, Szabó I, Song JW, Lee HJ, Bánóczi Z.   +5 more
europepmc   +1 more source

Site-specific post-translational modification detection by polar charged engineered MspA nanopores. [PDF]

Chem Sci
Lin S, Yi Y, Liu Y, Li M, Xia F, Wu HC, Lou X.   +6 more
europepmc   +1 more source