Results 1 to 10 of about 1,143 (101)

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines [PDF]

Pharmaceutics, 2023
Introduction: Hydrogel nanoparticles, also known as nanogels (NGs), have been recently proposed as alternative supramolecular vehicles for the delivery of biologically relevant molecules like anticancer drugs and contrast agents. The inner compartment of
Giovanni Smaldone, Elisabetta Rosa, Enrico Gallo, Carlo Diaferia, Giancarlo Morelli, Mariano Stornaiuolo, Antonella Accardo   +6 more
doaj   +5 more sources

Incorporation of PEG Diacrylates (PEGDA) Generates Hybrid Fmoc-FF Hydrogel Matrices [PDF]

Gels, 2022
Generated by a hierarchical and multiscale self-assembling phenomenon, peptide-based hydrogels (HGs) are soft materials useful for a variety of applications. Short and ultra-short peptides are intriguing building blocks for hydrogel fabrication.
Elisabetta Rosa, Enrico Gallo, Teresa Sibillano, Cinzia Giannini, Serena Rizzuti, Eliana Gianolio, Pasqualina Liana Scognamiglio, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia   +9 more
doaj   +9 more sources

Fmoc-FF Nanogel-Mediated Delivery of Doxorubicin and Curcumin in Thyroid Cancer Cells [PDF]

Pharmaceutics
Background: Thyroid cancer (TC) is the most prevalent endocrine malignancy, and is categorized into well-differentiated and aggressive anaplastic types. Novel therapeutic modalities are needed for TC.
Enrico Gallo, Giovanni Smaldone, Luca Cimmino, Mariantonia Braile, Francesca Maria Orlandella, Neila Luciano, Antonella Accardo, Giuliana Salvatore   +7 more
doaj   +5 more sources

Fmoc-FF hydrogels and nanogels for improved and selective delivery of dexamethasone in leukemic cells and diagnostic applications [PDF]

Scientific Reports
Dexamethasone (DEX) is a synthetic analogue of cortisol commonly used for the treatment of different pathological conditions, comprising cancer, ocular disorders, and COVID-19 infection.
Enrico Gallo, Carlo Diaferia, Giovanni Smaldone, Elisabetta Rosa, Giovanni Pecoraro, Giancarlo Morelli, Antonella Accardo   +6 more
doaj   +5 more sources

Peptide-Based Nanogels for Pharmaceutical and Biotechnological Applications: From Fmoc-FF to Other Peptide Sequences [PDF]

Pharmaceuticals
Peptide-based materials represent a rapidly growing field in nanotechnology, bridging bottom-up self-assembly and top-down approaches for the development of functional nanostructures.
Mariangela Rosa, Sabrina Marino, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia   +4 more
doaj   +3 more sources

Differently N‐Capped Analogues of Fmoc‐FF

Chemistry - A European Journal, 2023
AbstractShort and ultra‐short peptides have been recently envisioned as excellent building blocks for the formulation of hydrogels with appealing properties. Due to its simplicity and capability to gel under physiological conditions, Fmoc‐FF (Nα‐fluorenylmethoxycarbonyl‐diphenylalanine), remains one of the most studied low molecular‐weight ...
Antonella Accardo
exaly   +4 more sources

Biocompatible Dipeptide-Based Nanogels Incorporating Cinnamic Acid for Applications in Skin Disorder Therapy [PDF]

Pharmaceutics
Background/Objectives: Skin-related disorders such as melanoma, premature aging, and chronic wounds significantly impact individuals’ quality of life and psychological well-being.
Jülide Secerli, Burcu Karayavuz, Hakan Erdoğan, Merve Güdül Bacanlı   +3 more
doaj   +2 more sources

Evaluation of cationic peptide-based nanogels as delivery systems for negatively charged molecules: a formulative study [PDF]

Scientific Reports
Peptide-based nanogels (NGs) represent a cutting-edge class of nanoscale drug delivery systems. Due to their structural properties, NGs platforms can encapsulate and protect therapeutic agents (e.g.
Mariangela Rosa, Elisabetta Rosa, Valeria Castelletto, Ian W. Hamley, Giancarlo Morelli, Antonella Accardo, Carlo Diaferia   +6 more
doaj   +2 more sources

Dynamic pillar–perfusion platform for screening enzyme‐induced self‐assembling peptide therapeutics in 3D breast cancer spheroids [PDF]

Bioengineering & Translational Medicine
Enzyme‐induced self‐assembling peptides (EISAPs) are a promising class of enzyme‐activated anticancer therapeutics, yet their translational screening is limited by the lack of 3D tumor models that effectively capture drug penetration, self‐assembly ...
Andrea Escobar Martinez, Pranav Joshi, Emily Carney, Faye Fouladgar, Robert Powell, Manav Goud Vanga, Victoria Gnenema, Sarah Hripko, Moo‐Yeal Lee, Neda Habibi   +9 more
doaj   +2 more sources

Investigating the Interactions of Peptide Nucleic Acids with Multicomponent Peptide Hydrogels for the Advancement of Healthcare Technologies [PDF]

Gels
This study reports the development of peptide-based hydrogels for the encapsulation and controlled release of peptide nucleic acids in drug delivery applications.
Sabrina Giordano, Monica Terracciano, Enrico Gallo, Carlo Diaferia, Andrea Patrizia Falanga, Antonella Accardo, Monica Franzese, Marco Salvatore, Gennaro Piccialli, Nicola Borbone, Giorgia Oliviero   +10 more
doaj   +2 more sources