Results 41 to 50 of about 1,162 (118)

Histidine Ethylation by Histidine Methyltransferases SETD3 and METTL9

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Enzyme assays and computational analyses reveal that human histidine methyltransferases SETD3 and METTL9 have a capacity to catalyze histidine ethylation in the presence of synthetic or in situ produced S‐adenosylethionine (AdoEth) and Se‐adenosylselenoethionine (AdoSeEth) cosubstrates.
Jordi C. J. Hintzen, Zhimei Yu, Sadaf Ahmad, Xin Zhang, Yuan–Yuan Zhao, Hao Deng, Leonie Schütz, Marija Ram, Julia Z. Kaminska, Jakub Drozak, Elmar Weinhold, Hong Guo, Andrea Rentmeister, Ping Qian, Jasmin Mecinović   +14 more
wiley   +1 more source

Biocompatibility and Therapeutic Potential of Cinnamoyl‐Diphenylalanine Dipeptide: A Double‐Edged Sword

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Cin‐FF's biocompatibility is concentration and formulation (gel or solution) dependent, showing varied effects on bacterial strains and cell lines. ABSTRACT This study evaluates cinnamoyl‐diphenylalanine dipeptide (Cin‐FF), a newly introduced gelator, for its antimicrobial efficacy, biocompatibility, and potential anticancer properties in solution and ...
Efstratios D. Sitsanidis, Visa Ruokolainen, Kari Kunnas, Henna Rahkola, Lotta‐Riina Sundberg, Maija Vihinen‐Ranta, Mika Pettersson, Maija Nissinen   +7 more
wiley   +1 more source

Biomimetic Metallopeptidases for Biomedical Applications: From Modular Design to Disease Treatment

Rare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Biomimetic metallopeptidases, as an emerging class of artificial enzyme systems, have demonstrated tremendous application potential in the biomedical field in recent years. Their core design principle is to rationally control amino acid composition and three‐dimensional conformation so that programmable peptide sequences can efficiently ...
Ke Ma, Ke‐Zheng Chen, Sheng‐Lin Qiao
wiley   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, Volume 183, Issue 9, Page 1845-1859, May 2026.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin

International Journal of Nanomedicine, 2021
Enrico Gallo,1 Carlo Diaferia,2 Elisabetta Rosa,2 Giovanni Smaldone,1 Giancarlo Morelli,2 Antonella Accardo2 1IRCCS SDN, Naples, 80143, Italy; 2Department of Pharmacy and Research Centre on Bioactive Peptides (CIRPeB), University of Naples &ldquo ...
Gallo E, Diaferia C, Rosa E, Smaldone G, Morelli G, Accardo A   +5 more
doaj  

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

3D Printable Hydrogel Based on TEMPO-Oxidized Cellulose Nanofibrils and Fmoc-FF for Enhanced Biological Performance and Cell Adhesion

ACS Applied Nano Materials
Herein, we report a 3D printable ink made of a peptide-polysaccharide hybrid hydrogel composed of fluorenylmethyloxycarbonyl-diphenylalanine (Fmoc-FF) peptide and TEMPO-oxidized cellulose nanofibrils (ToCNF), synthesized using a pH-dependent sol–gel transition method.
Raveendran, Dhanya, Dalloul, Feras, Mietner, J. Benedikt, Barba, Enguerrand, Chen, Shouzheng, Zaytseva-Zotova, Daria, Sochor, Benedikt, Koyiloth Vayalil, Sarathlal, Müller-Buschbaum, Peter, Tiainen, Hanna, Roth, Stephan V., Navarro, Julien R. G.   +11 more
openaire   +2 more sources

Engineering Asymmetry: How Chirality Boosts Catalysis, Spin Selectivity, and Light–Matter Interactions

ChemPhotoChem, Volume 10, Issue 4, April 2026.
This review connects chiroptical spectroscopy, asymmetric catalysis, and spintronics, revealing how chirality influences the interactions of matter with light, charge, and spin. Across diverse systems, remarkable chiroptical effects emerge, showing among others that high efficiencies can arise without absolute enantiopurity, and that functionality is ...
Charitini Panagiotopoulou, Maedeh Anisi, Changseop Jeong, Kamyar Shameli, J. Lorenzo Alonso‐Gómez, Aras Kartouzian   +5 more
wiley   +1 more source

The Application of Metal–Organic Frameworks as Drug Delivery Systems: From the Perspective of Molecular Dynamics Simulations

MedComm, Volume 7, Issue 4, April 2026.
This review article provides a comprehensive exploration of the synergistic integration of molecular dynamics (MD) simulations and metal–organic frameworks (MOFs) to advance the design and optimization of nanoscale drug delivery systems (DDSs). We believe this work will be of significant interest to researchers in nanomedicine, computational biology ...
Jiahao Xu, Hanzi Zheng, Yue Gao, Yuanqiu Lai, Mengya Peng, Yike Hu, Tianmeng Yuan, Xiang Liu, Shihan Zhou, Wei Duan, Jia‐Wei Shen, Yongke Zheng   +11 more
wiley   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source