Results 31 to 40 of about 1,162 (118)

Fmoc solid-phase synthesis of RF9 optimization with mass spectrometry verification

Current Issues in Pharmacy and Medical Sciences, 2022
The RF9 compound, which is an antagonist of the FF neuropeptide receptors is used as a therapeutic substance to improve the effectiveness of opioids in the chronic treatment of pain.
Orocz Marta, Hartman Kinga, Smoluch Marek, Silberring Jerzy, Mielczarek Przemyslaw   +4 more
doaj   +1 more source

Cyclo‐Polyproline: Chameleonic All‐Peptide Macrocycles With Induced‐Fit Host‐Guest Recognition

Angewandte Chemie, Volume 138, Issue 27, 1 July 2026.
Macrocycles served as the genesis of supramolecular chemistry, advancing synthetic, separation, and materials fields. Despite their utility, they typically lack synthetic control. This work establishes a robust platform for all‐peptide macrocycles capable of host‐guest complexation and chameleonic behavior.
Camilla Di Girolamo, Patricia C. Fleming, Caroline R. Kwawu, Amanda R. Guimarães, Jimmy Muldoon, Julia Bruno‐Colmenarez, Yannick Ortin, Michael R. Probert, Felipe Fantuzzi, Aniello Palma   +9 more
wiley   +2 more sources

Bioinspired Co‐Assembly Enables Multiscale Architected Hydrogels for 3D Printing With Integrated Antibacterial and Bioactive Functions

Advanced Functional Materials, EarlyView.
A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov, Francesca Netti, Sigal Rencus‐Lazar, Moran Aviv, Lihi Adler‐Abramovich   +4 more
wiley   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Extracellular matrix formation in self-assembled minimalistic bioactive hydrogels based on aromatic peptide amphiphiles

Journal of Tissue Engineering, 2014
The hitherto inconsistency in clinical performance for engineered skin drives the current development of novel cell-scaffolding materials; one challenge is to only extract essential characteristics from the complex native ECM (extracellular matrix) and ...
Mi Zhou, Rein V Ulijn, Julie E Gough
doaj   +1 more source

Hierarchical Peptide Functionalized Titania Nanotubes: Improving Stability, Promoting Osteogenesis, and Reducing Infection Risk

Small, EarlyView.
The study demonstrates a dual‐level modification of titania nanotube surfaces through the covalent grafting of Fmoc‐FF dipeptides, followed by a secondary self‐assembled layer of FF dipeptide. This hierarchical strategy significantly enhances coating density and structural integrity without compromising the nano‐topographical and biochemical cues ...
Ramesh Singh, Ketul C Popat
wiley   +1 more source

Studying Phosphoroorganic Modification of Smac‐Mimetics to Boost Selectivity for cIAP1‐BIR3 and Unravel cIAP1/XIAP Molecular Inhibition Mechanisms

Asian Journal of Organic Chemistry, Volume 15, Issue 7, July 2026.
The phosphoroorganic modification of Smac‐mimetics (SMs) drives selectivity for cIAP1‐ over XIAP‐BIR3. The divalent SM 6 partially dimerizes cIAP1, whereas it prefers intramolecular binding in XIAP. In XIAP the phosphoroorganic moiety of the monovalent SM 7 functions as an IBM, thus inhibiting both BIR2 and BIR3. Created in BioRender.
Elisa Fagnani, Paolo Cocomazzi, Waldemar Goldeman, Marcin Sieńczyk, Francesco Bonì, Mona Amini Baghbadorani, Agnieszka Łupicka‐Słowik, Federica Cossu   +7 more
wiley   +1 more source

Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels

Heliyon
The presented research highlights a novel approach using fmoc-protected peptide hydrogels for the encapsulation and stretching of mesenchymal stem cells (MSCs).
Farzaneh Fouladgar, Forough Ghasem Zadeh Moslabeh, Yashesh Varun Kasani, Nick Rogozinski, Marc Torres, Melanie Ecker, Huaxiao Yang, Yong Yang, Neda Habibi   +8 more
doaj   +1 more source

Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION A subset of Alzheimer's disease (AD) patients exhibits a procoagulant state that remains undiagnosed despite available treatments. We developed positron emission tomography (PET) strategies to in vivo detect cerebral microthrombi in TgCRND8 mice. METHODS PET was performed with a fibrin‐binding probe (FBP) in TgCRND8 and wild‐type
Carlos Ceron, Marta Casquero‐Veiga, Nicolás Lamanna‐Rama, Irene Fernández‐Nueda, Alberto Fernández‐Pena, Nancy Olazagoitia, Gorka Sobrino, Aitor Herraiz, María Isabel González, María Muñoz‐Hernando, Alejandro Ruperti‐Repilado, Eduardo Romero‐Sanz, Miguel Ángel Morcillo, Carlos Pérez‐Medina, Maria Angeles Moro, Gonzalo Villaverde, Jorge Rubio, Jose Fernandez‐Ferro, Manuel Desco, Fernando Herranz, Beatriz Salinas, Valentin Fuster, Marta Cortes‐Canteli   +22 more
wiley   +1 more source