Results 21 to 30 of about 1,162 (118)

Multicomponent Peptide-Based Hydrogels Containing Chemical Functional Groups as Innovative Platforms for Biotechnological Applications

Gels, 2023
Multicomponent hydrogels (HGs) based on ultrashort aromatic peptides have been exploited as biocompatible matrices for tissue engineering applications, the delivery of therapeutic and diagnostic agents, and the development of biosensors.
Sabrina Giordano, Enrico Gallo, Carlo Diaferia, Elisabetta Rosa, Barbara Carrese, Nicola Borbone, Pasqualina Liana Scognamiglio, Monica Franzese, Giorgia Oliviero, Antonella Accardo   +9 more
doaj   +1 more source

Nanoscale Piezoelectric Properties of Self-Assembled Fmoc–FF Peptide Fibrous Networks [PDF]

ACS Applied Materials & Interfaces, 2015
Fibrous peptide networks, such as the structural framework of self-assembled fluorenylmethyloxycarbonyl diphenylalanine (Fmoc-FF) nanofibrils, have mechanical properties that could successfully mimic natural tissues, making them promising materials for tissue engineering scaffolds.
Ryan, Kate, Beirne, Jason, Redmond, Gareth, Kilpatrick, J. I., Guyonnet, Jill, Buchete, Nicolae-Viorel, Kholkin, Andrei L., Rodriguez, Brian J.   +7 more
openaire   +6 more sources

Fmoc-diphenylalanine-based hydrogels as a potential carrier for drug delivery

e-Polymers, 2020
High concentrations of IDM drugs can be incorporated into hydrogels during the self-assembly of Fmoc-FF. Small amounts of PAMAM added to the hydrogel (Fmoc-FF 0.5%–IDM 0.5%–PAMAM 0.03%) resulted in more prolonged IDM release when compared with Fmoc-FF 0 ...
Choe Ranjoo, Il Yun Seok
doaj   +1 more source

Revisiting the Self-Assembly of Highly Aromatic Phenylalanine Homopeptides

Molecules, 2020
Diphenylalanine peptide (FF), which self-assembles into rigid tubular nanostructures, is a very short core recognition motif in Alzheimer’s disease β-amyloid (Aβ) polypeptide.
Enric Mayans, Carlos Alemán
doaj   +1 more source

Peptide-based scaffolds for the culture and maintenance of primary human hepatocytes

Scientific Reports, 2021
We report here the use of a nanofibrous hydrogel as a 3D scaffold for the culture and maintenance of functional primary human hepatocytes. The system is based on the cooperative assembly of a fiber-forming peptide component, fluorenylmethyloxycarbonyl ...
Douglas MacPherson, Yaron Bram, Jiwoon Park, Robert E. Schwartz   +3 more
doaj   +1 more source

Poly(acrylic acid)/Dipeptide Double-Network Hydrogel to Achieve a Highly Stretchable Strain Sensor

Chemosensors, 2022
Flexible and stretchable strain sensors can be applied for human health monitoring and disease diagnoses via the output of multiple biophysical signals. However, it is still a challenge to fabricate short-peptide-based strain sensors. Here, we prepared a
Xin Luo, Boya Ding, Xingcen Liu
doaj   +1 more source

Self-Supporting Hydrogels Based on Fmoc-Derivatized Cationic Hexapeptides for Potential Biomedical Applications

Biomedicines, 2021
Peptide-based hydrogels (PHGs) are biocompatible materials suitable for biological, biomedical, and biotechnological applications, such as drug delivery and diagnostic tools for imaging.
Carlo Diaferia, Elisabetta Rosa, Enrico Gallo, Giovanni Smaldone, Mariano Stornaiuolo, Giancarlo Morelli, Antonella Accardo   +6 more
doaj   +1 more source

Integrin receptor-binding nanofibrous peptide hydrogel for combined mesenchymal stem cell therapy and nitric oxide delivery in renal ischemia/reperfusion injury

Stem Cell Research & Therapy, 2022
Background Mesenchymal-based therapy has been utilized as a practical approach in the treatment of renal ischemia/reperfusion (I/R) injury. However, low cell retention and survival in the ischemic site have remained challenging issues. To bridge this gap,
Haniyeh Najafi, Samira Sadat Abolmaali, Reza Heidari, Hadi Valizadeh, Ali Mohammad Tamaddon, Negar Azarpira   +5 more
doaj   +1 more source

Substrate selectivity of human histidine methyltransferase METTL9. [PDF]

Protein Sci
Abstract Methylation of histidine residues in zinc transporters by histidine methyltransferase METTL9 plays an important role in modulating their metal‐binding properties. Here, we report synthetic, enzymatic, and computational studies on human METTL9‐catalyzed Nπ‐methylation of His375 in zinc transporter SLC39A5‐derived peptides in which the histidine
Ahmad S, Moesgaard L, Tornøe CW, Emmel P, Slusarczyk K, Drozak J, Kongsted J, Mecinović J.   +7 more
europepmc   +2 more sources

Expanding the Functional Scope of the Fmoc‐Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification

Advanced Science, 2019
Peptidomimetic low‐molecular‐weight hydrogelators, a class of peptide‐like molecules with various backbone amide modifications, typically give rise to hydrogels of diverse properties and increased stability compared to peptide hydrogelators.
Vasantha Basavalingappa, Tom Guterman, Yiming Tang, Sivan Nir, Jiangtao Lei, Priyadarshi Chakraborty, Lee Schnaider, Meital Reches, Guanghong Wei, Ehud Gazit   +9 more
doaj   +1 more source