Results 241 to 250 of about 134,053 (282)

Interfacing B‐DNA and DNA Mimic Foldamers

Angewandte Chemie International Edition, EarlyView.
Helical aromatic oligoamide DNA mimic foldamers that reproduce the shape and charge distribution of duplex B‐DNA have been interfaced with DNA duplexes by means of a new linker that serves both as a DNA hairpin and as an aromatic oligoamide unit. In the resulting chimeric molecules, the linker does not perturb the DNA duplex structure and converts the ...
Manuel Loos, Felix Xu, Pradeep K. Mandal, Tulika Chakrabortty, Céline Douat, David B. Konrad, Melis Cabbar, Johannes Singer, Valentina Corvaglia, Thomas Carell, Ivan Huc   +10 more
wiley   +1 more source

Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups

Angewandte Chemie International Edition, Accepted Article.
Protein‐based tools are emerging as innovative solutions to interfere with biological pathways in molecular biology and medicine. They offer advantages over traditional small molecules due to their adaptable structural diversity and their ability to engage previously inaccessible cellular targets.
Jonathan Franke, Jan Vincent V. Arafiles, Leis Christian, Christian Hackenberger   +3 more
wiley   +1 more source

PCR‐Free Site‐Directed Mutagenesis on Repetitive Sequences Using Single‐Stranded DNA‐Assisted Double‐Stranded DNA Nicking by DNAzymes

Angewandte Chemie International Edition, Accepted Article.
Site‐directed mutagenesis (SDM) is a key driver for many biochemical investigations and biotechnological applications. Despite decades of development, it is still difficult to perform SDM on some sequences, including highly repetitive ones, because polymerase chain reaction (PCR) is often used as the most effective method for SDM, but results in ...
Mingkuan Lyu, Linggen Kong, Xiangli Shao, Yi Lu   +3 more
wiley   +1 more source

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis

Angewandte Chemie International Edition, Accepted Article.
Solid‐phase peptide synthesis has become an indispensable technique for the routine preparation of linear peptides of up to ~40 amino acids in length. However, the solid‐phase approach is still hampered by chain insolubility and aggregation, which reduces synthetic yields.
Samuel L Paravizzini, Linda M Haugaard-Kedström, Craig A Hutton, John Andrew Karas   +3 more
wiley   +1 more source

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Fluorinated Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Marcel Hollenstein, Daniel Gautschi, Christian J. Leumann   +2 more
openaire   +4 more sources

Application of peptide nucleic acid in electrochemical nucleic acid biosensors

Biopolymers, 2021
AbstractThe early diagnosis of major diseases, such as malignant tumors, has always been an important field of research. Through screening, early detection of such diseases, and timely and effective treatment can significantly improve the survival rate of patients and reduce medical costs.
Haobo Sun, Haobo Sun, Jinming Kong, Xueji Zhang   +3 more
openaire   +3 more sources

Hybridization of Peptide Nucleic Acid

Biochemistry, 1998
The thermodynamics of hybridization and the conformations of decameric mixed purine-pyrimidine sequence PNA/PNA, PNA/DNA, and DNA/DNA duplexes have been studied using fluorescence energy transfer (FET), absorption hypochromicity (ABS), isothermal titration calorimetry (ITC), and circular dichroism (CD) techniques.
Ratilainen, T., Holmén, A., Tuite, E., Haaima, G., Christensen, L., Nielsen, Peter Eigil, Nordén, B.   +6 more
openaire   +3 more sources

Peptide-Templated Nucleic Acid Ligation [PDF]

Journal of Molecular Evolution, 2003
Short oligonucleotide and peptide replicators have been described. To determine whether cross-replication could have occurred between such systems, we have attempted to show that peptides can specifically template the ligation of nucleic acids. A complex between a 35-mer anti-Rev RNA aptamer and a 17-mer arginine-rich motif (ARM) peptide from the HIV-1
Matthew Levy, Andrew D. Ellington
openaire   +2 more sources

Facile synthesis of peptide nucleic acids and peptide nucleic acid‐peptide conjugates on an automated peptide synthesizer

Journal of Peptide Science, 2010
AbstractPeptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence‐specific manner.
Joshi, R., Jha, D., Su, W., Engelmann, J.   +3 more
openaire   +4 more sources

Olefinic Peptide Nucleic Acid (OPA)

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Christian J. Leumann, Daniel Gautschi
openaire   +4 more sources