Results 251 to 260 of about 134,053 (282)

Peptide Nucleic Acids for MicroRNA Targeting

2020
The involvement of microRNAs in human pathologies is firmly established. Accordingly, the pharmacological modulation of microRNA activity appears to be a very interesting approach in the development of new types of drugs (miRNA therapeutics). One important research area is the possible development of miRNA therapeutics in the field of rare diseases. In
Gambari R., Gasparello J., Fabbri E., Borgatti M., Tamanini A., Finotti A.   +5 more
openaire   +3 more sources

Cyclopentane Peptide Nucleic Acids

2013
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
Ning Zhang, Ethan A. Englund, Daniel H. Appella   +2 more
openaire   +3 more sources

Nucleobase Modified Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Robert H. E. Hudson, Russell D. Viirre, N. McCourt, J. Tse   +3 more
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Peptide Nucleic Acids [PDF]

, 1998
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole, Engholm, Michael, Nielsen, Peter E., Berg, Rolf Henrik   +3 more
openaire   +2 more sources

Pretargeting using peptide nucleic acid

Cancer, 1997
Pretargeting studies in animals and humans have usually involved (strept)avidin and biotin. Depending on the particular strategy, endogenous biotin can adversely influence localization when these molecules are used.As an alternative to (strept)avidin and biotin, we have explored the use of a single-stranded peptide nucleic acid (PNA) bound to a protein
Mary Rusckowski, F. Chang, Donald Hnatowich, T. Qu   +3 more
openaire   +3 more sources

Applications of peptide nucleic acids

Current Opinion in Biotechnology, 1999
Several exciting new developments in the applications of the DNA mimic peptide nucleic acid (PNA) have been published recently. A possible breakthrough may have come in efforts to develop PNA into gene therapeutic drugs. In eukaryotic systems, antisense activity of PNAs (as peptide conjugates) has been reported in nerve cells and even in rats upon ...
openaire   +3 more sources

The Chemistry of Peptide Nucleic Acids

ChemInform, 2001
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ralph A. Casale, Michael Egholm
openaire   +2 more sources

Peptide Nucleic Acids (PNAs)

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Arif Ali, Shabih Shakeel, Sajjad Karim
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Synthesis of Peptide Nucleic Acid–Peptide Conjugates

2004
Synthetic oligonucleotides are versatile tools for recognizing ribonucleic acid and deoxyribonucleic acid. This chapter describes methods for enhancing recognition by derivatizing oligonucleotides with either proteins or peptides.
David R. Corey, Kunihiro Kaihatsu
openaire   +2 more sources

Photocatalysis with nucleic acids and peptides

Physical Sciences Reviews, 2018
Abstract In chemical photocatalysis, the photophysical process is coupled to a subsequent chemical reaction. The absorbed light energy contributes to the overall energy balance of the reaction and thereby increases its sustainability. Additionally, oligonucleotides and oligopeptides offer the possibility to control regio- and stereoselectivity as ...
Alexander Penner, Sergej Hermann, Hans-Achim Wagenknecht, Arthur Kuhlmann, Michael Weinberger   +4 more
openaire   +2 more sources