Results 261 to 270 of about 765,071 (332)

Fimbriae‐Targeted Peptide‐Selenoviologen Cyclophane Complex for Enhanced Photodynamic Therapy of Periodontitis

Aggregate, EarlyView.
This study develops a supramolecular photosensitizer (SeVB⊃PQ) by combining SeVB with a P. gingivalis‐targeting peptide. SeVB⊃PQ selectively binds P. gingivalis, boosts ROS generation under irradiation, disrupts ATP synthesis, restores microbial balance, reduces inflammation, and promotes alveolar bone regeneration, offering a promising platform for ...
Rui Ding, Yawen Li, Yuchen Zhang, Qi Sun, Ang Li, Kun Zhou, Dandan Pei, Gang He   +7 more
wiley   +1 more source

Peptide Nucleic Acid Clamp-Assisted Photothermal Multiplexed Digital PCR for Identifying SARS-CoV-2 Variants of Concern. [PDF]

Adv Sci (Weinh)
Zhang L, Parvin R, Lin S, Chen M, Zheng R, Fan Q, Ye F.   +6 more
europepmc   +1 more source

Overcoming Clinical Barriers: Utilizing Self‐Assembly Systems to Break the Protease Limitations of Antimicrobial Peptides

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This study addresses AMPs' clinical application challenges by enhancing stability via molecular assembly. Pba* shows high antibacterial activity, biocompatibility, and low toxicity, paving the way for antimicrobial materials. ABSTRACT Natural antimicrobial peptides (AMPs) encounter significant challenges in transitioning to clinical application ...
Xu Guo, Weikang Yu, Qingrui Li, Xuefeng Li, Yingxin Wei, Jiajun Wang, Yinfeng Lyu, Anshan Shan   +7 more
wiley   +1 more source

Full‐Length FUS Protein Condensates Adopt a Domain‐Preferential Spatial Architecture

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We demonstrate a domain‐specific preferential distribution organization of FUS condensate and propose a sequence–structure–function paradigm for biomolecular condensates. ABSTRACT Biomolecular condensates play crucial roles in cellular physiology and are implicated in neurodegenerative diseases and cancer.
Si‐Cheng Tong, Yang Jiang, Yi‐Nan Guo, Yong Wang, Li Zhao, Zhong‐Yuan Lu   +5 more
wiley   +1 more source

Bacterial DNA‐Targeting AIE Photosensitizer for Efficient Eradication of Intracellular Bacteria and Biofilm‐Associated Infections

Aggregate, EarlyView.
A bacterial DNA‐targeted PS TPE‐CN for the precise treatment of MRSA‐associated infections has been developed. Through synergistic PDT effect, TPE‐CN damages bacterial DNA and membrane, resulting in effective elimination of planktonic bacteria, biofilm, and intracellular bacteria.
Yonghui Lv, Minyang Zhao, Qiaowen Lin, Zhiwen Xu, Qingqing Bai, Dan Ding, Duo Mao, Kang‐Nan Wang   +7 more
wiley   +1 more source

Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands

, 2008
Josephus Johannes Weterings
openalex   +2 more sources

Self-assembled antibody multimers through peptide nucleic acid conjugation.

Journal of the American Chemical Society, 2013
Stephanie A. Kazane, Jun Y Axup, Chan Hyuk Kim, M. Ciobanu, Erik D. Wold, S. Barluenga, Benjamin A Hutchins, P. Schultz, N. Winssinger, Vaughn V. Smider   +9 more
semanticscholar   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Potent antibacterial antisense peptide-peptide nucleic acid conjugates against Pseudomonas aeruginosa.

Nucleic Acid Therapeutics, 2012
A. Ghosal, P. Nielsen
semanticscholar   +1 more source

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics

Advanced Intelligent Systems, EarlyView.
This review outlines recent advances in integrating artificial intelligence with microphysiological systems for nanoparticle evaluation. It highlights data‐driven optimization, image‐based prediction, and AI‐enabled analysis frameworks that advance translational research and support the development of personalized nanomedicine. Nanoparticles (NPs) play
Yedam Lee, Jaehong Min, Sujin Kim, Jihoon Ko   +3 more
wiley   +1 more source