Results 91 to 100 of about 611,085 (327)
New strategies in Bioconjugation : chemical modification of nucleic acids and peptides [PDF]
, 2015 One of the open challenges in chemical biology is to identify reactions that proceed with large rate constants in water at neutral pH values. Once assembled, these conjugates may be used for a broad variety of applications (e.g., therapeutics, imaging ...
Schmidt, Pascal Jarno
core +1 more source
Advanced Materials, EarlyView.Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi +3 more
wiley +1 more source
Veterinary World, 2013 Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi +5 more
doaj +1 more source
Biointegrated Battery‐Based Electroceuticals
Advanced Materials, EarlyView.Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou +6 more
wiley +1 more source
Optimization of synthetic route to PNA-T-OH monomers
Journal of the Turkish Chemical Society, Section A: Chemistry, 2018 Peptide nucleic acids are synthetic molecules crafted to mimic natural nucleic acids, and thus, they are widely utilized in many chemical, and, biomedical applications.
Onur Alptürk, Z. Sevcan Yeşilbaş
doaj +1 more source
Peptide Nucleic Acids Synthesis and Analysis [PDF]
, 2022 Peptide nucleic acids (PNAs) are oligonucleotide analogues with the sugar-phosphate backbone replaced by the pseudopeptide skeleton, functioning as antigene/antisense chemical agents, initially designed by Nielson and coworkers.
Nguyen, Kat
core
Advanced Materials Interfaces, EarlyView.Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley +1 more source
Quantification of plasma HIV RNA using chemically-engineered peptide nucleic acids
Nature Communications, 2014 The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of molecules ideal to develop as part of a diagnostic device.
Chao Zhao +6 more
semanticscholar +1 more source
Peptide Nucleic Acids Having Enhanced Binding Affinity and Sequence Specificity [PDF]
, 1998 A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity.
Engholm, Michael +3 more
core
Aminopeptidase C of Aspergillus niger is a Novel Phenylalanine Aminopeptidase [PDF]
, 2003 A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share ...
Dekker, P.J.T. +2 more
core +1 more source