Results 91 to 100 of about 1,472,861 (289)
Tailoring Peptide Nucleic Acids for Enhanced RNA-Targeting
, 2023 Peptide nucleic acids (PNAs) represent nucleic acid mimics featuring a peptide backbone composed of N-(2-aminoethyl)glycine units, deviating from the conventional sugar-phosphate core.
Lenz, Agnes +3 more
core +3 more sources
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang +13 more
wiley +1 more source
Conjugation and Interaction Studies of Thiol Peptide-based Hydrogels and Peptide Nucleic Acids [PDF]
Peptide Nucleic Acids (PNAs) are synthetic analogues of nucleic acids whose backbones consist of N–(2- aminoethyl)glycine repeats, anchored via amidic bonds.
N. Borbone +6 more
core
, 2007 We have developed 2'-O-methyloligoribonucleotide and peptide nucleic acid (PNA) based artificial ribonucleases (OBAN's), which in presence of zinc or copper ions cleave a potential therapy target in leukemia, an M-BCR/ABL mRNA model.
Strömberg, R,, Murtola, M,
core +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
Peptide Nucleic Acids Having Enhanced Binding Affinity and Sequence Specificity [PDF]
, 1998 A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity.
Engholm, Michael +3 more
core
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source
Peptide Nucleic Acids Having 2,6-Diaminopurine Nucleobases [PDF]
, 2003 A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity.
Engholm, Michael +3 more
core