Results 71 to 80 of about 1,472,861 (289)
Polyanionic Carboxyethyl Peptide Nucleic Acids (ce-PNAs): Synthesis and DNA Binding.
PLoS ONE, 2015 New polyanionic modifications of polyamide nucleic acid mimics were obtained. Thymine decamers were synthesized from respective chiral α- and γ-monomers, and their enantiomeric purity was assessed. Here, we present the decamer synthesis, purification and
Yuliya Kirillova +9 more
doaj +1 more source
Peptide-Based Nanoassemblies in Gene Therapy and Diagnosis: Paving the Way for Clinical Application
Molecules, 2020 Nanotechnology approaches play an important role in developing novel and efficient carriers for biomedical applications. Peptides are particularly appealing to generate such nanocarriers because they can be rationally designed to serve as building blocks
Shabnam Tarvirdipour +4 more
doaj +1 more source
Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle
Advanced Functional Materials, EarlyView.This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang +18 more
wiley +1 more source
Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
Molecules, 2020 Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing.
Nicholas G. Economos +5 more
doaj +1 more source
Higher Order Structure and Binding of Peptide Nucleic Acids [PDF]
, 2004 Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity
Engholm, Michael +4 more
core
The isolation of nucleic acids from fixed, paraffin-embedded tissues-which methods are useful when? [PDF]
, 2007 Museums and pathology collections around the world represent an archive of genetic material to study populations and diseases. For preservation purposes, a large portion of these collections has been fixed in formalin-containing solutions, a treatment ...
Haselkorn, Tamara +35 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj +23 more
wiley +1 more source
Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis
Molecules, 2017 The monitoring of DNA and RNA biomarkers freely circulating in the blood constitutes the basis of innovative cancer detection methods based on liquid biopsy.
Roberta D’Agata +2 more
doaj +1 more source
Cleaving Double-Stranded DNA with Peptide Nucleic Acids [PDF]
, 1997 Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity
Engholm, Michael +5 more
core
, 2014 Peptide nucleic acids (PNAs) have been developed for applications in biotechnology and therapeutics. There is great potential in the development of chemically modified PNAs or other triplex-forming ligands that selectively bind to RNA duplexes, but not ...
Lu, Yunpeng +4 more
core +1 more source