Results 61 to 70 of about 794,375 (291)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Controlled assembly of SNAP-PNA-fluorophore systems on DNA templates to produce fluorescence resonance energy transfer [PDF]

, 2014
The SNAP protein is a widely used self-labeling tag that can be used for tracking protein localization and trafficking in living systems. A model system providing controlled alignment of SNAP-tag units can provide a new way to study clustering of fusion ...
Bader A. N., Bannwarth M., Brun M. A., Campos C., Carrion-Vazquez M., Chakrabarti R., Dadon Z., Daguer J. P., Diaz-Mochon J. J., Donovan C., Feldkamp U., Gautier I., Gholami Z., Gorska K., Gronemeyer T., Harris J. L., Haruki H., Hermanson G. T., Hinner M. J., Huang K.-T., Hussain A. F., Hutchins B. M., Johnsson K., Johnsson N., Juillerat A., Jung D., Kamiya M., Kampmeier F., Kazane S. A., Keppler A., Keppler A., Keppler A., Keppler A., Komatsu T., Lakowicz J. R., Lin M. Z., Lo P. K., Lovrinovic M., Lu H., Maurel D., Menchise V., Niemeyer C. M., Niemeyer C. M., Niemeyer C. M., O’Hare H. M., Pianowski Z. L., Pin J. P., Pouchain D., Prencipe G., Quentin Hanley, Roloff A., Rothemund P. W. K., Rothlingshofer M., Rozners E., Runnels L. W., Sadhu K. K., Scheibe C., Scheibe C., Scheibe C., Seeman N. C., Spinelli N., Sun X., Svensen N., Urbina H. D., Weber G., Weber G., Winssinger N., Yeow E. K. L., Zahra Gholami, Zolmajd-Haghighi Z.   +69 more
core   +1 more source

A Peptide–Nucleic Acid Replicator Origin for Life [PDF]

Trends in Ecology & Evolution, 2020
Evolution requires self-replication. But, what was the very first self-replicator directly ancestral to all life? The currently favoured RNA World theory assigns this role to RNA alone but suffers from a number of seemingly intractable problems. Instead, we suggest that the self-replicator consisted of both peptides and nucleic acid strands.
Piette, Bernard M.A.G., Heddle, Jonathan G.   +1 more
openaire   +5 more sources

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Role of Cell-Penetrating Peptides in Intracellular Delivery of Peptide Nucleic Acids Targeting Hepadnaviral Replication

Molecular Therapy: Nucleic Acids, 2017
Peptide nucleic acids (PNAs) are potentially attractive antisense agents against hepatitis B virus (HBV), although poor cellular uptake limits their therapeutic application.
B. Ndéboko, N. Ramamurthy, G. Lémamy, C. Jamard, P. Nielsen, L. Cova   +5 more
semanticscholar   +1 more source

Non-transgenic Gene Modulation via Spray Delivery of Nucleic Acid/Peptide Complexes into Plant Nuclei and Chloroplasts

ACS Nano, 2022
Genetic engineering of economically important traits in plants is an effective way to improve global welfare. However, introducing foreign DNA molecules into plant genomes to create genetically engineered plants not only requires a lengthy testing period
Chonprakun Thagun, Yoko Horii, Maai Mori, Seiya Fujita, M. Ohtani, K. Tsuchiya, Y. Kodama, Masaki Odahara, K. Numata   +8 more
semanticscholar   +1 more source

Nanotechnology for Delivery of Peptide Nucleic Acids (PNA)

Journal of Controlled Release, 2016
Over the past three decades, peptide nucleic acids have been employed in numerous chemical and biological applications. Peptide nucleic acids possess enormous potential because of their superior biophysical properties, compared to other oligonucleotide ...
Anisha Gupta, R. Bahal, Meera Gupta, Meera Gupta, P. Glazer, W. Saltzman   +5 more
semanticscholar   +1 more source

Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases

Nucleic Acids Research, 2021
Cancer and neurodegenerative diseases are caused by genetic and environmental factors. Expression of tumour suppressor genes is suppressed by mutations or epigenetic silencing, whereas for neurodegenerative disease-related genes, nucleic acid-based ...
H. Tateishi-Karimata, N. Sugimoto
semanticscholar   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery. [PDF]

, 2012
In the forthcoming era of cancer gene therapy, efforts will be devoted to the development of new efficient and non-toxic gene delivery vectors. In this regard, the use of Fmoc/Boc-protected oligo(ethane amino)acids as building blocks for solid-phase ...
Akinc, Aumailley, Behr, Blessing, Boussif, Breunig, Carlos Mas-Moruno, Chollet, Christian Dohmen, Christina Troiber, Cotten, Cox, David Schaffert, Davis, Davis, Dechantsreiter, Desgrosellier, Drake, Edinger, Ellman, Erbacher, Ernest Giralt, Ernst Wagner, Felding-Habermann, Felgner, Fella, Grandinetti, Harbottle, Hartmann, Hartmann, Haubner, Horst Kessler, Irene Martin, J., Kantlehner, Kichler, Kim, Kursa, Li, Lin, Luthman, Madder, Mas-Moruno, McKenzie, Meritxell Teixidó, Merkel, Meyer, Meyer, Michael Günther, Moghimi, Mosca, Nie, Oba, Oupicky, Pack, Petra Kos, Pfaff, Plank, Reis, Ruoslahti, Russ, Russ, Schaffert, Schaffert, Schaffert, Schiffelers, Sonawane, Trubetskoy, Ulrich Lächelt, Varkouhi, Wagner, Wagner, Wagner, Wagner, Walker, Wu, Xia, Xu, Zintchenko   +78 more
core   +3 more sources