Efficient cell penetration and delivery of peptide nucleic acids by an argininocalix[4]arene
Scientific Reports, 2019 The application of Peptide Nucleic Acids (PNAs), mimics of DNA lacking the sugar-phosphate backbone, for antisense/anti-gene therapy and gene editing is limited by their low uptake by cells. Currently, no simple and efficient delivery systems and methods
Jessica Gasparello +6 more
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Time-Resolved Fluorescence Investigation of the Human Immunodeficiency Virus Type 1 Nucleocapsid Protein: Influence of the Binding of Nucleic Acids [PDF]
, 1999 Depending on the HIV-1 isolate, MN or BH10, the nucleocapsid protein, NCp7, corresponds to a 55- or 71-amino acid length product, respectively. The MN NCp7 contains a single Trp residue at position 37 in the distal zinc finger motif, and the BH10 NCp7 ...
Piemont, Etienne +13 more
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Cyanobacteria produce N-(2-aminoethyl)glycine, a backbone for peptide nucleic acids which may have been the first genetic molecules for life on Earth. [PDF]
PLoS ONE, 2012 Prior to the evolution of DNA-based organisms on earth over 3.5 billion years ago it is hypothesized that RNA was the primary genetic molecule. Before RNA-based organisms arose, peptide nucleic acids may have been used to transmit genetic information by ...
Sandra Anne Banack +5 more
doaj +1 more source
Selected strategies to fight pathogenic bacteria
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for ...
Aiva Plotniece +13 more
doaj +1 more source
Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry
Journal of Nucleic Acids, 2012 “Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability.
Charlotte Förster +6 more
doaj +1 more source
Peptide nucleic acids: Advanced tools for biomedical applications
Journal of Biotechnology, 2017 Highlights • Peptide Nucleic Acids − DNA/RNA analogues.• Different Modifications on PNA backbone and their effects.• Neutral backbone − remarkable hybridization properties.• PNA based biosensors and their diverse biomedical applications.• Potential ...
Anjali Gupta, A. Mishra, N. Puri
semanticscholar +1 more source
Formulation of PLGA nanoparticles containing short cationic peptide nucleic acids
MethodsX, 2020 Peptide nucleic acids (PNAs) have emerged as one of the most versatile tools with a wide range of biomedical applications including antisense, antimiR, antigene, as well as site-specific gene editing.
Shipra Malik, Frank J Slack, Raman Bahal
doaj +1 more source
Synthesis and Purification of Peptide Nucleic Acids [PDF]
Current Protocols in Nucleic Acid Chemistry, 2002 AbstractPeptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A. +2 more
openaire +3 more sources
Development of 2'-o-methyloligoribonucleotide and peptide nucleic acid based artificial ribonucleases [PDF]
, 2007 We have developed 2'-O-methyloligoribonucleotide and peptide nucleic acid (PNA) based artificial ribonucleases (OBAN's), which in presence of zinc or copper ions cleave a potential therapy target in leukemia, an M-BCR/ABL mRNA model.
Strömberg, R,, Murtola, M,
core +1 more source
Journal of the Royal Society Interface, 2022 Recent developments in Origins of Life research have focused on substantiating the narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular weight, a paradigm that typically sidelines the roles of peptides. Nevertheless,
S. Fried +4 more
semanticscholar +1 more source