Results 21 to 30 of about 1,472,861 (289)
Applied Sciences, 2022 Peptide nucleic acid (PNA) is an analog of natural nucleic acids, where the sugar-phosphate backbone of DNA is replaced by an electrostatically neutral N-(2-aminoethyl)glycine backbone.
Yuichiro Aiba +2 more
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Biomolecules, 2023 The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek +4 more
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Antibacterial Peptide Nucleic Acids—Facts and Perspectives
Molecules, 2020 Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.
Monika Wojciechowska +4 more
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Peptide Nucleic Acids: Applications in Biomedical Sciences
Molecules, 2020 The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
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Multifunctional Delivery Systems for Peptide Nucleic Acids
Pharmaceuticals, 2020 The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a polyamide backbone—is continuously increasing in both in vitro and cellular systems and, parallel to this, delivery systems able to bring PNAs to their targets have
Stefano Volpi +3 more
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The folding propensity of α/sulfono-γ-AA peptidic foldamers with both left- and right-handedness
Communications Chemistry, 2021 Controlling the helical structure of peptide foldamers requires detailed understanding of the relationship between primary and secondary structure. Here the effect of monomer stoichiometry and configuration on the helical structures of peptide nucleic ...
Peng Teng +10 more
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Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures
Nature Communications, 2020 Nucleic acid-based materials are usually only compatible with aqueous solutions. Here, the authors show a structural nucleic acid nanotechnology using gamma-modified peptide nucleic acids that enables formation of solvent-compatible, self-assembling ...
Sriram Kumar +3 more
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Potential of Peptide Nucleic Acids in Future Therapeutic Applications [PDF]
Advanced Pharmaceutical Bulletin, 2018 Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker.
Soheila Montazersaheb +2 more
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Peptide Nucleic Acid Microarrays [PDF]
, 2004 A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette, Jacob +3 more
openaire +2 more sources
Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]
, 2011 Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber +3 more
core +1 more source