Results 21 to 30 of about 611,085 (327)
Journal of Colloid and Interface Science, 2022 The development of systems able to deliver genetic material into a target site is a challenge for modern medicine. Single-stranded peptide nucleic acids have attracted attention as promising therapeutic molecules for diagnostic and gene therapy. However,
M. Massaro +9 more
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Artificial genetic polymers against human pathologies
Biology Direct, 2022 Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community.
Gleb S. Ivanov +6 more
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Applied Sciences, 2022 Peptide nucleic acid (PNA) is an analog of natural nucleic acids, where the sugar-phosphate backbone of DNA is replaced by an electrostatically neutral N-(2-aminoethyl)glycine backbone.
Yuichiro Aiba +2 more
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A minimal hybridization chain reaction (HCR) system using peptide nucleic acids
Chemical Science, 2021 The HCR represents a powerful tool for amplification in DNA-based circuitry and sensing applications, yet requires the use of long DNA sequences to grant hairpin metastability.
Ki Tae Kim +2 more
semanticscholar +1 more source
Biomolecules, 2023 The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek +4 more
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Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.
Nucleic Acids Research, 2021 We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (Tm) of PNA+DNA duplexes by ...
Hongchao Zheng +7 more
semanticscholar +1 more source
, 2002 A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility.
Engholm, Michael +4 more
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Peptide Nucleic Acids: Applications in Biomedical Sciences
Molecules, 2020 The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
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A self-replicating peptide nucleic acid [PDF]
Org. Biomol. Chem., 2014 This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
Plöger, Tobias A. +1 more
openaire +3 more sources
The folding propensity of α/sulfono-γ-AA peptidic foldamers with both left- and right-handedness
Communications Chemistry, 2021 Controlling the helical structure of peptide foldamers requires detailed understanding of the relationship between primary and secondary structure. Here the effect of monomer stoichiometry and configuration on the helical structures of peptide nucleic ...
Peng Teng +10 more
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