Results 11 to 20 of about 1,472,861 (289)
Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) [PDF]
Ultrasonics Sonochemistry, 2023 Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS).
Alessandra Del Bene +9 more
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Subtractive modification of bacterial consortium using antisense peptide nucleic acids [PDF]
Frontiers in Microbiology, 2023 Microbiome engineering is an emerging research field that aims to design an artificial microbiome and modulate its function. In particular, subtractive modification of the microbiome allows us to create an artificial microbiome without the microorganism ...
Tatsuya Hizume +6 more
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Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae [PDF]
Microbiology Spectrum, 2022 Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for multiple other infectious diseases, such as meningitis and otitis media, in children.
Gina Barkowsky +7 more
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Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids
Molecular Therapy: Nucleic Acids, 2021 Peptide nucleic acids (PNAs), a synthetic DNA mimic, have been extensively utilized for antisense- and antigene-based biomedical applications. Significant efforts have been made to increase the cellular uptake of PNAs, but here we examined relatively ...
Shipra Malik +2 more
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Therapeutic and diagnostic applications of antisense peptide nucleic acids [PDF]
Molecular Therapy: Nucleic AcidsPeptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
Victoria MacLelland +2 more
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Antibacterial activities of novel peptide nucleic acids targeting Salmonella penicillin-binding proteins [PDF]
Molecular Therapy: Nucleic AcidsSalmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential
Mohamed El-Fateh +4 more
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Peptide Nucleic Acids Promise New Therapeutics and Gene Editing Tools [PDF]
ACS Central Science, 2023 Rachel Brazil
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, 2002 A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility.
EGHOLM MICHAEL +7 more
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THE GALA PEPTIDE: MULTIPLE ROLES IN DRUG AND GENE DELIVERY [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2020 Therapeutic nucleic acids must be formulated in delivery systems that permit them to be efficiently targeted to specific tissues within the body and to overcome the endosomal barrier to deliver these molecules to their intracellular target sites. GALA is
Hideyoshi Harashima, Ikramy Khalil
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Artificial genetic polymers against human pathologies
Biology Direct, 2022 Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community.
Gleb S. Ivanov +6 more
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