Results 11 to 20 of about 794,375 (291)
Therapeutic and diagnostic applications of antisense peptide nucleic acids. [PDF]
Mol Ther Nucleic Acids, 2023 Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
MacLelland V, Kravitz M, Gupta A.
europepmc +2 more sources
Peptide Nucleic Acids Promise New Therapeutics and Gene Editing Tools. [PDF]
ACS Cent Sci, 2023 DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast for millennia.
Brazil R.
europepmc +2 more sources
Exploiting protected maleimides to modify oligonucleotides, peptides and peptide nucleic acids [PDF]
Molecules, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Brun Cubero, Omar +3 more
core +3 more sources
Antibacterial Peptide Nucleic Acids-Facts and Perspectives. [PDF]
Molecules, 2020 Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.
Wojciechowska M +4 more
europepmc +2 more sources
Multifunctional Delivery Systems for Peptide Nucleic Acids. [PDF]
Pharmaceuticals (Basel), 2020 The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a polyamide backbone—is continuously increasing in both in vitro and cellular systems and, parallel to this, delivery systems able to bring PNAs to their targets have
Volpi S +3 more
europepmc +2 more sources
Advanced Materials, 2016 Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics.
Thomas A Werfel +2 more
exaly +2 more sources
The challenge of peptide nucleic acid synthesis
Chemical Society Reviews, 2023 The main strategies for the synthesis of Peptide Nucleic Acids (PNAs): key molecules as DNA/RNA mimics that can hybridize complementary chains of nucleic acids with high affinity and specificity.
K. P. Nandhini +3 more
openaire +3 more sources
Beilstein Journal of Organic Chemistry, 2021 Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a most dramatic departure from the native structure of DNA. The present review summarizes 30 years of research on PNA’s chemistry, optimization of structure and ...
N. Brodyagin +4 more
semanticscholar +1 more source
Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids [PDF]
Molecular Therapy - Nucleic Acids, 2021 W Mark Saltzman, Raman Bahal
exaly +2 more sources
A minimal hybridization chain reaction (HCR) system using peptide nucleic acids
Chemical Science, 2021 The HCR represents a powerful tool for amplification in DNA-based circuitry and sensing applications, yet requires the use of long DNA sequences to grant hairpin metastability.
Ki Tae Kim +2 more
semanticscholar +1 more source