Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer. [PDF]
Journal of the American Chemical Society, 2019 Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to adopt complex ...
Colin S. Swenson +3 more
semanticscholar +2 more sources
Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae [PDF]
Microbiology Spectrum, 2022 Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for multiple other infectious diseases, such as meningitis and otitis media, in children.
Gina Barkowsky +7 more
doaj +2 more sources
Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids
Molecules, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris +3 more
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Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
Molecules, 2020 Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing.
Nicholas G. Economos +5 more
doaj +2 more sources
Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing
Molecules, 2018 Peptide nucleic acids (PNAs) can bind duplex DNA in a sequence-targeted manner, forming a triplex structure capable of inducing DNA repair and producing specific genome modifications.
Adele S. Ricciardi +4 more
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Advanced Materials, 2016 Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics.
Kasey Vickers +2 more
exaly +2 more sources
The challenge of peptide nucleic acid synthesis
Chemical Society Reviews, 2023 The main strategies for the synthesis of Peptide Nucleic Acids (PNAs): key molecules as DNA/RNA mimics that can hybridize complementary chains of nucleic acids with high affinity and specificity.
K. P. Nandhini +3 more
openaire +3 more sources
Incorporation of thio-pseudoisocytosine into triplex-forming peptide nucleic acids for enhanced recognition of RNA duplexes [PDF]
Nucleic Acids Research, 2014 Peptide nucleic acids (PNAs) have been developed for applications in biotechnology and therapeutics. There is great potential in the development of chemically modified PNAs or other triplex-forming ligands that selectively bind to RNA duplexes, but not ...
Gitali Devi +4 more
semanticscholar +2 more sources
Antibacterial activities of novel peptide nucleic acids targeting Salmonella penicillin-binding proteins [PDF]
Molecular Therapy: Nucleic AcidsSalmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential
Mohamed El-Fateh +4 more
doaj +2 more sources
THE GALA PEPTIDE: MULTIPLE ROLES IN DRUG AND GENE DELIVERY [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2020 Therapeutic nucleic acids must be formulated in delivery systems that permit them to be efficiently targeted to specific tissues within the body and to overcome the endosomal barrier to deliver these molecules to their intracellular target sites. GALA is
Hideyoshi Harashima, Ikramy Khalil
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