Results 31 to 40 of about 611,085 (327)

Peptide nucleic acids in materials science [PDF]

Artificial DNA: PNA & XNA, 2012
This review highlights the recent methods to prepare PNA-based materials through a combination of self-assembly and self-organization processes. The use of these methods allows easy and versatile preparation of structured hybrid materials showing specific recognition properties and unique physicochemical properties at the nano- and micro-scale levels ...
D. Bonifazi, * L.-E. Carloni, V. Corvaglia, A. Delforge   +3 more
openaire   +3 more sources

Peptide Nucleic Acid Microarrays [PDF]

, 2004
A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette, Jacob, Ole, Brandt, Achim, Stephan, Jörg D, Hoheisel   +3 more
openaire   +2 more sources

Morphology and Applications of Self-Assembled Peptide Nucleic Acids. [PDF]

Int J Mol Sci
Obtaining new materials by exploiting the self-assembly of biomolecules is a very challenging field. In recent years, short peptides and nucleic acids have been used as scaffolds to produce supramolecular structures for different applications in the ...
D'Andrea LD, Romanelli A.
europepmc   +2 more sources

Rational Design Problematics of Peptide Nucleic Acids as SARS-CoV‑2 Inhibitors [PDF]

ACS Omega
Tatyana A. Grigoreva, Svetlana V. Vorona, Daria S. Novikova, Vyacheslav G. Tribulovich   +3 more
doaj   +2 more sources

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber, Troiber, Christina, Wagner, Ernst, Ernst Wagner   +3 more
core   +1 more source

Peptide Nucleic Acids

Methods in Molecular Biology, 2014
P. Nielsen, D. Appella
openaire   +2 more sources

Peptides for nucleic acid delivery

Advanced Drug Delivery Reviews, 2016
Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells.
Lehto, T, Ezzat, K, Wood, M, El Andaloussi, S   +3 more
openaire   +3 more sources

Silencing disease genes in the laboratory and the clinic [PDF]

, 2011
Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before
Jonathan K Watts, David R Corey, Corey, David R., Watts, Jonathan K.   +3 more
core   +1 more source

Detection of target DNA using fluorescent cationic polymer and peptide nucleic acid probes on solid support

BMC Biotechnology, 2005
Background Nucleic acids detection using microarrays requires labelling of target nucleic acids with fluorophores or other reporter molecules prior to hybridization.
Leclerc Mario, Picard François J, Boissinot Maurice, Bissonnette Luc, Peytavi Régis, Ho Hoang-Anh, Raymond Frédéric R, Bergeron Michel G   +7 more
doaj   +1 more source

Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities

Molecules, 2015
Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA.
Takuya Akisawa, Yuki Ishizawa, Fumi Nagatsugi   +2 more
doaj   +1 more source