Results 161 to 170 of about 794,375 (291)

Antibacterial activities of novel peptide nucleic acids targeting <i>Salmonella</i> penicillin-binding proteins. [PDF]

Mol Ther Nucleic Acids
El-Fateh M, Viau C, Ahmed N, Xia J, Zhao X.   +4 more
europepmc   +1 more source

Synthesis of Bifacial Peptide Nucleic Acids with Diketopiperazine Backbones. [PDF]

Synlett, 2022
Devari S, Bhunia D, Bong D.
europepmc   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

5-Triazolyl uracil improves nucleobase stacking, pyrimidine recognition, biological activity, and specificity of RNA-binding triplex-forming peptide nucleic acids. [PDF]

Nucleic Acids Res
Saei SF, Endoh T, Baskevics V, Kumpina I, Katkevics M, Sugimoto N, Rozners E.   +6 more
europepmc   +1 more source

Cationic Calix[4]arene Vectors to Efficiently Deliver AntimiRNA Peptide Nucleic Acids (PNAs) and miRNA Mimics. [PDF]

Pharmaceutics, 2023
Gasparello J, Papi C, Zurlo M, Volpi S, Gambari R, Corradini R, Casnati A, Sansone F, Finotti A.   +8 more
europepmc   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Peptide nucleic acids in parallel orientation form invasion complexes with double-stranded DNA. [PDF]

RSC Chem Biol
Shibata M, Sugimoto H, Hibino M, Shoji O, Aiba Y.   +4 more
europepmc   +1 more source

Multivalent Lactobionic Acid and N-Acetylgalactosamine-Conjugated Peptide Nucleic Acids for Efficient In Vivo Targeting of Hepatocytes. [PDF]

Adv Healthc Mater, 2023
Kumar V, Wahane A, Gupta A, Manautou JE, Bahal R.   +4 more
europepmc   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

<i>γ</i>-Amino Carboxylic Acid Modification Enhances the Efficacy of Peptide Nucleic Acids Targeting miR-221-3p in Lung Cancer Cell Lines. [PDF]

Curr Issues Mol Biol
Yoon Y, Joo NR, Kim T, Bae D, Lee S, Pak S, Min J, Park J, Choi Y.   +8 more
europepmc   +1 more source