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Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real‐World Data

Advanced Intelligent Discovery, EarlyView.
This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley   +1 more source

Development of an in situ small intestinal injection technique for targeted macromolecule delivery and in vivo functional studies in mice

Animal Models and Experimental Medicine, EarlyView.
This study developed a minimally invasive, in situ small intestinal injection technique for mice, enabling targeted delivery of bioactive molecules while bypassing gastric degradation. Validation using functional assays and single‐cell RNA sequencing reveals high‐mobility group box 1–mediated epithelial responses, offering a translational tool for gut ...
Yawen Lai, Xintao Zhang, Tingting Luo, Wenhan Chen, Chenyu Ma, Haihua Luo, Jinghua Liu, Jia Xu   +7 more
wiley   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

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Mechanisms and applications of peptide nucleic acids selectively binding to double‐stranded RNA

Biopolymers, 2021
RNAs form secondary structures containing double‐stranded base paired regions and single‐stranded regions. Probing, detecting and modulating RNA structures and dynamics requires the development of molecular sensors that can differentiate the sequence and
X. Zhan, Liping Deng, Gang Chen
semanticscholar   +1 more source

Application strategies of peptide nucleic acids toward electrochemical nucleic acid sensors.

In Analysis, 2021
Peptide nucleic acids (PNAs) have attracted tremendous interest in the fabrication of highly sensitive electrochemical nucleic acid biosensors due to their higher stability and increased sensitivity than common DNA probes.
Qingteng Lai, Wei Chen, Yanke Zhang, Zhengchun Liu   +3 more
semanticscholar   +1 more source

Fluorinated Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Marcel, Hollenstein, Daniel, Gautschi, Christian J, Leumann   +2 more
openaire   +2 more sources

Peptide nucleic acids harness dual information codes in a single molecule.

Chemical Communications, 2020
Nature encodes the information required for life in two fundamental biopolymers: nucleic acids and proteins. Peptide nucleic acid (PNA), a synthetic analog comprised of nucleobases arrayed along a pseudopeptide backbone, has the ability to combine the ...
Colin S. Swenson, J. Heemstra
semanticscholar   +1 more source

Olefinic Peptide Nucleic Acid (OPA)

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Daniel, Gautschi, Christian J, Leumann
openaire   +2 more sources

Cyclopentane Peptide Nucleic Acids

2013
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
Ethan A, Englund, Ning, Zhang, Daniel H, Appella   +2 more
openaire   +2 more sources