Results 301 to 310 of about 677,914 (356)

A Versatile Disulfide‐Containing Solid‐Support Strategy for 3′‐Modifiers in Oligonucleotides: Introducing Modular Tandem Oligonucleotide Synthesis

Chemistry – An Asian Journal, EarlyView.
We report a versatile disulfide‐containing linkage to solid support that enables on‐column synthesis of DNA and RNA containing a 3′‐amino or 3′‐phosphate group. This orthogonal solid‐support linker enables a protecting group strategy for the synthesis of oligonucleotides containing 3′‐amino‐2′,3′‐dideoxyribosides directly from commercially available ...
Jagandeep S. Saraya, Nicholas G. Horton, Michael J. Capperauld, Evan Zakaria, Derek K. O'Flaherty   +4 more
wiley   +1 more source

Selection of DNA Aptamers Against Parathyroid Hormone for Electrochemical Impedimetric Biosensor System Development

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT This work presents the pioneering development of an aptamer‐based electrochemical biosensor for real‐time monitoring of parathyroid hormone (PTH) levels, with a focus on intraoperative assessment during parathyroid surgery. It introduces, for the first time, the selection and characterization of aptamers targeting distinct segments of the PTH ...
Reza Didarian, Saharnaz Bargh, Almina Gülerman, Veli Cengiz Özalp, Özcan Erel, Nimet Yildirim‐Tirgil   +5 more
wiley   +1 more source

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

Cell‐Penetrating Peptide‐Based Triple Nanocomplex Enables Efficient Nuclear Gene Delivery in Chlamydomonas reinhardtii

Biotechnology and Bioengineering, EarlyView.
A novel strategy for nuclear gene delivery in microalgae using a cell‐penetrating peptide (CPP) and nuclear localization signal (NLS) is described. The authors developed a triple nanocomplex of CPP, plasmid DNA, and SV40 NLS to enhance nuclear delivery in Chlamydomonas reinhardtii.
Eun Jeong Sim, Quynh‐Giao Tran, Yu Rim Lee, Trang Thi Le, Hyang Ran Yoon, Dong‐Yun Choi, Dae‐Hyun Cho, Jin‐Ho Yun, Hong Il Choi, Hee‐Sik Kim, Yong Jae Lee   +10 more
wiley   +1 more source

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Peptide nucleic acids harness dual information codes in a single molecule.

Chemical Communications, 2020
Nature encodes the information required for life in two fundamental biopolymers: nucleic acids and proteins. Peptide nucleic acid (PNA), a synthetic analog comprised of nucleobases arrayed along a pseudopeptide backbone, has the ability to combine the ...
Colin S. Swenson, J. Heemstra
semanticscholar   +1 more source

Fluorinated Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Marcel Hollenstein, Daniel Gautschi, Christian J. Leumann   +2 more
openaire   +4 more sources

Application of peptide nucleic acid in electrochemical nucleic acid biosensors

Biopolymers, 2021
AbstractThe early diagnosis of major diseases, such as malignant tumors, has always been an important field of research. Through screening, early detection of such diseases, and timely and effective treatment can significantly improve the survival rate of patients and reduce medical costs.
Haobo Sun, Haobo Sun, Jinming Kong, Xueji Zhang   +3 more
openaire   +3 more sources

Hybridization of Peptide Nucleic Acid

Biochemistry, 1998
The thermodynamics of hybridization and the conformations of decameric mixed purine-pyrimidine sequence PNA/PNA, PNA/DNA, and DNA/DNA duplexes have been studied using fluorescence energy transfer (FET), absorption hypochromicity (ABS), isothermal titration calorimetry (ITC), and circular dichroism (CD) techniques.
Ratilainen, T., Holmén, A., Tuite, E., Haaima, G., Christensen, L., Nielsen, Peter Eigil, Nordén, B.   +6 more
openaire   +3 more sources

Quantum Dot-Based Molecular Beacons for Quantitative Detection of Nucleic Acids with CRISPR/Cas(N) Nucleases.

ACS Nano, 2022
Strategies utilizing the CRISPR/Cas nucleases Cas13 and Cas12 have shown great promise in the development of highly sensitive and rapid diagnostic assays for the detection of pathogenic nucleic acids.
Christopher M. Green, J. Spangler, K. Susumu, D. Stenger, Igor L. Medintz, S. A. Díaz   +5 more
semanticscholar   +1 more source