Results 281 to 290 of about 608,469 (324)

Cyclopentane Peptide Nucleic Acids

2013
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
Ethan A, Englund, Ning, Zhang, Daniel H, Appella   +2 more
openaire   +2 more sources

Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids

Current Pharmaceutical Design, 2019
BACKGROUND Peptide nucleic acids (PNAs) belong to the next generation of synthetic nucleic acid analogues. Their high binding affinity and specificity towards the target DNA or RNA make them the reagent of choice for gene therapy-based applications ...
Raman Bahal
exaly   +2 more sources

Quantum Dot-Based Molecular Beacons for Quantitative Detection of Nucleic Acids with CRISPR/Cas(N) Nucleases.

ACS Nano, 2022
Strategies utilizing the CRISPR/Cas nucleases Cas13 and Cas12 have shown great promise in the development of highly sensitive and rapid diagnostic assays for the detection of pathogenic nucleic acids.
Christopher M. Green, J. Spangler, K. Susumu, D. Stenger, Igor L. Medintz, S. A. Díaz   +5 more
semanticscholar   +1 more source

Peptide nucleic acids: a review on recent patents and technology transfer

Expert Opinion on Therapeutic Patents, 2014
Roberto Gambari
exaly   +2 more sources

Peptide Nucleic Acids

Methods in Molecular Biology, 2014
P. Nielsen, D. Appella
openaire   +2 more sources

Applications of peptide nucleic acids

Current Opinion in Biotechnology, 1999
Several exciting new developments in the applications of the DNA mimic peptide nucleic acid (PNA) have been published recently. A possible breakthrough may have come in efforts to develop PNA into gene therapeutic drugs. In eukaryotic systems, antisense activity of PNAs (as peptide conjugates) has been reported in nerve cells and even in rats upon ...
openaire   +2 more sources

Peptide nucleic acids: Expanding the scope of nucleic acid recognition

Trends in Biotechnology, 1997
Peptide nucleic acids (PNAs) are DNA analogs containing neutral amide backbone linkages. PNAs are stable to degradation by enzymes and hybridize to complementary sequences with higher affinity than analogous DNA oligomers. PNA synthesis employs protocols derived from solid-phase peptide synthesis, making the methodology straightforward and flexible ...
openaire   +2 more sources

Antisense properties of peptide nucleic acid

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999
Peptide nucleic acid (PNA) is a nucleic acid mimic in which the deoxyribose phosphate backbone has been replaced by a pseudo-peptide polymer to which the nucleobases are linked. PNA-oligomers can be synthesized in relatively large amounts, are highly stable in biological environments, and bind complementary DNA and RNA targets with remarkably high ...
Larsen, H J, Bentin, T, Nielsen, Peter E.   +2 more
openaire   +3 more sources

Antisense Properties of Peptide Nucleic Acid

1998
The hybridization properties of peptide nucleic acid (PNA) combined with its ease of synthesis and high chemical and biological stability rapidly made this molecule a very attractive lead compound for the development of antisense gene therapeutic drugs.
openaire   +2 more sources

Nucleobase Modified Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
R H E, Hudson, R D, Viirre, N, McCourt, J, Tse   +3 more
openaire   +2 more sources