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Journal of Colloid and Interface Science, 2022
The development of systems able to deliver genetic material into a target site is a challenge for modern medicine. Single-stranded peptide nucleic acids have attracted attention as promising therapeutic molecules for diagnostic and gene therapy. However,
M. Massaro +9 more
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The development of systems able to deliver genetic material into a target site is a challenge for modern medicine. Single-stranded peptide nucleic acids have attracted attention as promising therapeutic molecules for diagnostic and gene therapy. However,
M. Massaro +9 more
semanticscholar +1 more source
Mechanisms and applications of peptide nucleic acids selectively binding to double‐stranded RNA
Biopolymers, 2021RNAs form secondary structures containing double‐stranded base paired regions and single‐stranded regions. Probing, detecting and modulating RNA structures and dynamics requires the development of molecular sensors that can differentiate the sequence and
X. Zhan, Liping Deng, Gang Chen
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Application strategies of peptide nucleic acids toward electrochemical nucleic acid sensors.
In Analysis, 2021Peptide nucleic acids (PNAs) have attracted tremendous interest in the fabrication of highly sensitive electrochemical nucleic acid biosensors due to their higher stability and increased sensitivity than common DNA probes.
Qingteng Lai +3 more
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Advanced Materials, 2016 Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics.
Thomas A Werfel +2 more
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Application of peptide nucleic acid in electrochemical nucleic acid biosensors
Biopolymers, 2021AbstractThe early diagnosis of major diseases, such as malignant tumors, has always been an important field of research. Through screening, early detection of such diseases, and timely and effective treatment can significantly improve the survival rate of patients and reduce medical costs.
Haobo Sun, Jinming Kong, Xueji Zhang
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Recent advances on application of peptide nucleic acids as a bioreceptor in biosensors development
Trends in Analytical Chemistry (TrAC), 2019The analogs of DNA are unique biomedical tools that are broadly utilized to develop different types of biosensors. Peptide nucleic acids (PNA) are an individual and notable class of nucleic acid analogs due to their unique, novel physicochemical and ...
Arezoo Saadati +6 more
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Peptide nucleic acids harness dual information codes in a single molecule.
Chemical Communications, 2020Nature encodes the information required for life in two fundamental biopolymers: nucleic acids and proteins. Peptide nucleic acid (PNA), a synthetic analog comprised of nucleobases arrayed along a pseudopeptide backbone, has the ability to combine the ...
Colin S. Swenson, J. Heemstra
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Hybridization of Peptide Nucleic Acid
Biochemistry, 1998The thermodynamics of hybridization and the conformations of decameric mixed purine-pyrimidine sequence PNA/PNA, PNA/DNA, and DNA/DNA duplexes have been studied using fluorescence energy transfer (FET), absorption hypochromicity (ABS), isothermal titration calorimetry (ITC), and circular dichroism (CD) techniques.
Ratilainen, T. +6 more
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Journal of Peptide Science, 2010
AbstractPeptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence‐specific manner.
Joshi, R. +3 more
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AbstractPeptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence‐specific manner.
Joshi, R. +3 more
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Emerging technologies in the design of peptide nucleic acids (PNAs) based biosensors
, 2020From the first investigations on peptide nucleic acids (PNA), peculiar features have been described as intrinsic of the singular chemical nature of these biomolecules.
M. Moccia +5 more
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