Results 271 to 280 of about 611,085 (327)

Peptide nucleic acids: a review on recent patents and technology transfer

Expert Opinion on Therapeutic Patents, 2014
Roberto Gambari
exaly   +2 more sources

Application of peptide nucleic acid in electrochemical nucleic acid biosensors

Biopolymers, 2021
AbstractThe early diagnosis of major diseases, such as malignant tumors, has always been an important field of research. Through screening, early detection of such diseases, and timely and effective treatment can significantly improve the survival rate of patients and reduce medical costs.
Haobo Sun, Jinming Kong, Xueji Zhang
openaire   +2 more sources

Recent advances on application of peptide nucleic acids as a bioreceptor in biosensors development

Trends in Analytical Chemistry (TrAC), 2019
The analogs of DNA are unique biomedical tools that are broadly utilized to develop different types of biosensors. Peptide nucleic acids (PNA) are an individual and notable class of nucleic acid analogs due to their unique, novel physicochemical and ...
Arezoo Saadati, Soodabeh Hassanpour, M. Guardia, J. Mosafer, M. Hashemzaei, A. Mokhtarzadeh, B. Baradaran   +6 more
semanticscholar   +1 more source

Peptide nucleic acids harness dual information codes in a single molecule.

Chemical Communications, 2020
Nature encodes the information required for life in two fundamental biopolymers: nucleic acids and proteins. Peptide nucleic acid (PNA), a synthetic analog comprised of nucleobases arrayed along a pseudopeptide backbone, has the ability to combine the ...
Colin S. Swenson, J. Heemstra
semanticscholar   +1 more source

Hybridization of Peptide Nucleic Acid

Biochemistry, 1998
The thermodynamics of hybridization and the conformations of decameric mixed purine-pyrimidine sequence PNA/PNA, PNA/DNA, and DNA/DNA duplexes have been studied using fluorescence energy transfer (FET), absorption hypochromicity (ABS), isothermal titration calorimetry (ITC), and circular dichroism (CD) techniques.
Ratilainen, T., Holmén, A., Tuite, E., Haaima, G., Christensen, L., Nielsen, Peter Eigil, Nordén, B.   +6 more
openaire   +2 more sources

Facile synthesis of peptide nucleic acids and peptide nucleic acid‐peptide conjugates on an automated peptide synthesizer

Journal of Peptide Science, 2010
AbstractPeptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence‐specific manner.
Joshi, R., Jha, D., Su, W., Engelmann, J.   +3 more
openaire   +3 more sources

Emerging technologies in the design of peptide nucleic acids (PNAs) based biosensors

, 2020
From the first investigations on peptide nucleic acids (PNA), peculiar features have been described as intrinsic of the singular chemical nature of these biomolecules.
M. Moccia, Amina Antonacci, M. Saviano, Veronica Caratelli, F. Arduini, V. Scognamiglio   +5 more
semanticscholar   +1 more source

Cyclopentane Peptide Nucleic Acids

2013
Incorporating a cyclopentane ring into the two-carbon unit of a peptide nucleic acid backbone increases its binding affinity to complementary nucleic acid sequences. This approach is a general method to improve binding and can be applied at either purine or pyrimidine bases.
Ethan A, Englund, Ning, Zhang, Daniel H, Appella   +2 more
openaire   +2 more sources

Peptide Nucleic Acids: From Origami to Editing [PDF]

ChemPlusChem
First published: 07 July 2024Peptide nucleic acids (PNAs) combine the programmability of native nucleic acids with the robustness and ease of synthesis of a peptide backbone. These designer biomolecules have demonstrated tremendous utility across a broad
Emma Watson
exaly   +2 more sources

Quantum Dot-Based Molecular Beacons for Quantitative Detection of Nucleic Acids with CRISPR/Cas(N) Nucleases.

ACS Nano, 2022
Strategies utilizing the CRISPR/Cas nucleases Cas13 and Cas12 have shown great promise in the development of highly sensitive and rapid diagnostic assays for the detection of pathogenic nucleic acids.
Christopher M. Green, J. Spangler, K. Susumu, D. Stenger, Igor L. Medintz, S. A. Díaz   +5 more
semanticscholar   +1 more source