Results 261 to 270 of about 611,085 (327)
Some of the next articles are maybe not open access.
Peptide Nucleic Acids: Recent Developments in the Synthesis and Backbone Modifications
Bioorganic Chemistry, 2023Nucleic acid represents the ideal drug candidate for protein targets that are hard to target or against which drug development is not easy. Peptide nucleic acids (PNAs) are synthesized by attaching modified peptide backbones generally derived from ...
Gurpreet Singh, Vikramdeep Monga
exaly +2 more sources
Fluorinated Peptide Nucleic Acid [PDF]
Nucleosides, Nucleotides and Nucleic Acids, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Hollenstein M, Gautschi D, Leumann CJ
openaire +4 more sources
Olefinic Peptide Nucleic Acid (OPA) [PDF]
Nucleosides, Nucleotides and Nucleic Acids, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Gautschi D, Leumann CJ
openaire +4 more sources
Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids
Current Pharmaceutical Design, 2019BACKGROUND Peptide nucleic acids (PNAs) belong to the next generation of synthetic nucleic acid analogues. Their high binding affinity and specificity towards the target DNA or RNA make them the reagent of choice for gene therapy-based applications ...
Raman Bahal
exaly +2 more sources
Peptide Nucleic Acids for MicroRNA Targeting [PDF]
, 2020 The involvement of microRNAs in human pathologies is firmly established. Accordingly, the pharmacological modulation of microRNA activity appears to be a very interesting approach in the development of new types of drugs (miRNA therapeutics). One important research area is the possible development of miRNA therapeutics in the field of rare diseases. In
Gambari R. +5 more
openaire +4 more sources
, 1998 A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole +3 more
openaire +5 more sources
Peptide Nucleic Acids Complexes of Two Peptide Nucleic Acid Strands and One [PDF]
, 1999 Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of
Ecker, David J. +5 more
openaire +3 more sources
Mechanisms and applications of peptide nucleic acids selectively binding to double‐stranded RNA
Biopolymers, 2021RNAs form secondary structures containing double‐stranded base paired regions and single‐stranded regions. Probing, detecting and modulating RNA structures and dynamics requires the development of molecular sensors that can differentiate the sequence and
X. Zhan, Liping Deng, Gang Chen
semanticscholar +1 more source
Inhibition of miRNA Maturation by Peptide Nucleic Acids [PDF]
, 2013 Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and processing pathways. Antisense oligonucleotides or analogs are actually employed for the inhibition of miRNA function. Here we illustrate how Peptide Nucleic Acids oligomers targeting pre-miRNA are exploited to inhibit miRNA maturation.
Avitabile C +4 more
openaire +5 more sources
Application strategies of peptide nucleic acids toward electrochemical nucleic acid sensors.
In Analysis, 2021Peptide nucleic acids (PNAs) have attracted tremendous interest in the fabrication of highly sensitive electrochemical nucleic acid biosensors due to their higher stability and increased sensitivity than common DNA probes.
Qingteng Lai +3 more
semanticscholar +1 more source