Results 331 to 340 of about 677,914 (356)
Some of the next articles are maybe not open access.

Peptide Nucleic Acids

2010
PNA, antisense, antigene ...
openaire   +1 more source

Nucleobase Modifications in Peptide Nucleic Acids

Current Topics in Medicinal Chemistry, 2007
Peptide nucleic acid (PNA) is an oligonucleotide mimic originally designed upon a repeating N-(2-aminoethyl)glycine polyamide backbone to which nucleobase heterocycles are attached through a methylene carbonyl linkage to the alpha-amino group. These molecules possess remarkable hybridization properties with DNA or RNA forming complexes with high ...
Robert H. E. Hudson, Filip Wojciechowski
openaire   +3 more sources

Peptide Nucleic Acids

2007
Peptide nucleic acids (PNAs) can be conveniently delivered into cells in complex with DNA and cationic lipid. This advance enables researchers to test the hypothesis that PNAs offer advantages for recognition of DNA or RNA targets within cells. In this review, I describe the intracellular delivery of PNAs as DNA-PNA-cationic lipid complexes and discuss
openaire   +2 more sources

Antisense properties of peptide nucleic acids

Frontiers in Bioscience, 1999
PNA is a nucleic acid analog with an achiral polyamide backbone consisting of N-(2-aminoethyl)glycine units (figure 1). The purine or pyrimidine bases are linked to the each unit via a methylene carbonyl linker (1-3) to target the complementary nucleic acid (4).
Ursel Soomets   +2 more
openaire   +3 more sources

Inhibition of miRNA Maturation by Peptide Nucleic Acids [PDF]

open access: possible, 2013
Molecules able to interfere in miRNA genesis and function are potent tools to unravel maturation and processing pathways. Antisense oligonucleotides or analogs are actually employed for the inhibition of miRNA function. Here we illustrate how Peptide Nucleic Acids oligomers targeting pre-miRNA are exploited to inhibit miRNA maturation.
Avitabile C   +4 more
openaire   +4 more sources

Antisense properties of peptide nucleic acid

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999
Peptide nucleic acid (PNA) is a nucleic acid mimic in which the deoxyribose phosphate backbone has been replaced by a pseudo-peptide polymer to which the nucleobases are linked. PNA-oligomers can be synthesized in relatively large amounts, are highly stable in biological environments, and bind complementary DNA and RNA targets with remarkably high ...
Larsen, H J   +2 more
openaire   +4 more sources

Peptide nucleic acid and amino acid modified peptide nucleic acid analysis by capillary zone electrophoresis

ELECTROPHORESIS, 2019
AbstractA rapid, high resolution, and low sample consumption CZE method is developed for peptide nucleic acid (PNA) analysis for the first time. 30% v/v acetonitrile in PNA sample and 20% v/v acetonitrile in 50 mM borax‐boric acid (pH 8.7) as BGE were employed after optimization.
Xiaoqian Wang   +3 more
openaire   +3 more sources

Peptide nucleic acids are an additional class of aptamers

, 2013
Peptide nucleic acids (PNAs) have been known for their similar or superior properties to DNA or RNA since 1991, but not regarded as a separate class of aptamers.
Eun Jeong Lee   +3 more
semanticscholar   +1 more source

Antisense Properties of Peptide Nucleic Acid

1998
The hybridization properties of peptide nucleic acid (PNA) combined with its ease of synthesis and high chemical and biological stability rapidly made this molecule a very attractive lead compound for the development of antisense gene therapeutic drugs.
openaire   +3 more sources

ChemInform Abstract: Peptide Nucleic Acids: Analogues and Derivatives

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Ganesh, Krishna N., Nielsen, Peter Eigil
openaire   +3 more sources

Home - About - Disclaimer - Privacy