Results 41 to 50 of about 5,781 (240)

Combination of [¹⁷⁷Lu]Lu-DOTA-TATE Targeted Radionuclide Therapy and Photothermal Therapy as a Promising Approach for Cancer Treatment: In Vivo Studies in a Human Xenograft Mouse Model

Pharmaceutics, 2022
Peptide receptor radionuclide therapy (PRRT) relies on α- and β-emitting radionuclides bound to a peptide that commonly targets somatostatin receptors (SSTRs) for the localized killing of tumors through ionizing radiation.
Marina Simón, Jesper Tranekjær Jørgensen, Harshvardhan A. Khare, Camilla Christensen, Carsten Haagen Nielsen, Andreas Kjaer   +5 more
doaj   +1 more source

Thymic Neuroendocrine Tumor Presenting With Cervical Lymphadenopathy: A Case Report and Diagnostic Challenge. [PDF]

Clin Case Rep
ABSTRACT Thymic neuroendocrine tumors are rare and may initially present with isolated cervical lymphadenopathy. Early recognition and a multidisciplinary diagnostic approach are crucial for timely identification, accurate localization, and curative resection.
Xie X, Tang J, Wang W, Yang D, Qin K.
europepmc   +2 more sources

The association of intra-therapeutic heterogeneity of somatostatin receptor expression with morphological treatment response in patients undergoing PRRT with [177Lu]-DOTATATE [PDF]

, 2019
AIM: Purpose of this study was to evaluate the association of the spatial heterogeneity (asphericity, ASP) in intra-therapeutic SPECT/ CT imaging of somatostatin receptor (SSR) positive metastatic gastroenteropancreatic neuroendocrine neoplasms (GEP ...
Amthauer, Holger, Apostolova, Ivayla, Furth, Christian, Genseke, Philipp, Ghazzawi, Sammy, Grosser, Oliver S., Hofheinz, Frank, Kreissl, Michael C., Rogasch, Julian M. M., Schatka, Imke, Wetz, Christoph   +10 more
core   +1 more source

Treatment of a mixed acinar-endocrine carcinoma with uptake on 68Gallium-DOTATOC positron emission tomography-computed tomography : a case report [PDF]

, 2017
The case of a 35-year old female patient with a diagnosis of metastatic mixed acinar-endocrine carcinoma (MAEC) is investigated in the present study.
De Both, Anneleen, De Man, Marc, Geboes, Karen, Hoorens, Anne, Troisi, Roberto, Van Vlierberghe, Hans   +5 more
core   +2 more sources

Gallium-68-somatostatin receptor PET/CT parameters as potential prognosticators for clinical time to progression after peptide receptor radionuclide therapy: a cohort study

European Journal of Hybrid Imaging, 2021
Background Early [68Ga]Ga-DOTA-TOC PET/CT imaging after peptide receptor radionuclide therapy (PRRT) in neuroendocrine neoplasm patients is often used as a prognosticator for survival, but lacks validity.
Sander C. Ebbers, Muriël Heimgartner, Maarten W. Barentsz, Rachel S. van Leeuwaarde, Mark J. C. van Treijen, Marnix M. E. G. Lam, Arthur J. A. T. Braat   +6 more
doaj   +1 more source

[111In-DTPA]octreotide tumor uptake in GEPNET liver metastases after intra-arterial administration: An overview of preclinical and clinical observations and implications for tumor radiation dose after peptide radionuclide therapy [PDF]

, 2014
Aims: With the aim to improve peptide receptor radionuclide therapy effects in patients with gastroenteropancreatic neuroendocrine tumor (GEPNET) liver metastases we explored the effect of intra-arterial (IA) administration of [111In-DTPA]octreotide ...
Breeman, W.A.P. (Woulter), Eijck, C.H.J. (Casper) van, Hagen, T.L.M. (Timo) ten, Jong, M. (Marcel) de, Kam, B.L. (Boen), Konijnenberg, M. (Mark), Koning, G.A. (Gerben), Krenning, E.P. (Eric), Pool, S.E. (Stefan)   +8 more
core   +2 more sources

Value of Peptide Receptor Radionuclide Therapy as Neoadjuvant Treatment in the Management of Primary Inoperable Neuroendocrine Tumors

Frontiers in Oncology, 2021
IntroductionNeuroendocrine neoplasms including neuroendocrine tumors (NETs) are often diagnosed as primary disseminated or inoperable. In those cases, systemic extensive therapy is necessary, but radical treatment is unlikely.
Marta Opalińska, Anna Sowa-Staszczak, Anna Grochowska, Helena Olearska, Alicja Hubalewska-Dydejczyk   +4 more
doaj   +1 more source

Highly Symptomatic Progressing Cardiac Paraganglioma With Intracardiac Extension Treated With 177Lu-DOTATATE: A Case Report

Frontiers in Endocrinology, 2021
IntroductionPrimary cardiac paragangliomas are rare tumors. Metastatic disease is even rarer. Surgical management is technically challenging, and sometimes even impossible.
Alexis Huot Daneault, Mélanie Desaulniers, Jean-Mathieu Beauregard, Alexis Beaulieu, Frédéric Arsenault, Geneviève April, Éric Turcotte, François-Alexandre Buteau   +7 more
doaj   +1 more source

Induction of Anti-Tumor Immune Responses by Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE in a Murine Model of a Human Neuroendocrine Tumor

Diagnostics, 2013
Peptide receptor radionuclide therapy (PRRT) is a relatively new mode of internally targeted radiotherapy currently in clinical trials. In PRRT, ionizing radioisotopes conjugated to somatostatin analogues are targeted to neuroendocrine tumors (NETs) via ...
Michael Bzorek, Michael Holmsgaard Kristensen, Andreas Kjaer, Andreas Klaus Pfeifer, Ulrich Knigge, Yin Wu, Rajendra Singh Garbyal, Palle Rasmussen, Rebecca Myschetzky   +8 more
doaj   +1 more source

Clonal Hematopoiesis in Patients with Neuroendocrine Tumors Receiving Peptide Receptor Radionuclide Therapy (PRRT)

Blood, 2020
Background. Clonal hematopoiesis (CH) prevalence increases with age. Elderly (>70 years) healthy individuals have a 10% incidence of CH. Cancer cohorts are at increased risk of harboring CH mutations (~25%). Specific tumor types such as thyroid, ovarian, and bladder, have previously been shown to be at the highest risk of CH due to increased ...
Abhay Singh, Matthew Gravina, Rutaba Tajammal, Annmarie Nowak, Renuka Iyer, Mark G. Faber, LunBiao Yan, Duane C. Hassane, Monica L. Guzman, Nuria Mencia-Trinchant, Eunice S. Wang, Swapna Thota   +11 more
openaire   +1 more source