Results 101 to 110 of about 939,420 (304)

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Adjuvanted RNA Origami—A Tunable Peptide Assembly Platform for Constructing Cancer Nanovaccines

Vaccines
Background/Objectives: Cancer peptide vaccines represent a promising strategy to develop targeted and personalized treatments for cancer patients.
Theresa Yip, Xinyi Tu, Xiaodong Qi, Hao Yan, Yung Chang   +4 more
doaj   +1 more source

The marginal willingness-to-pay for attributes of a hypothetical HIV vaccine [PDF]

, 2012
This paper estimates the marginal willingness-to-pay for attributes of a hypothetical HIV vaccine using discrete choice modeling. We use primary data from 326 respondents from Bangkok and Chiang Mai, Thailand, in 2008–2009, selected using purposive ...
Newman, Peter A., Newman, PA, P. A. Newman, S. Roungprakhon, Newman, P.A., Cameron, MP, Scarpa, R., Scarpa, R, Scarpa, Riccardo, Roungprakhon, S, Cameron, Michael P., Cameron, Michael Patrick, Cameron, M.P., Roungprakhon, S., Roungprakhon, Surachet, M. P. Cameron   +15 more
core   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine

, 2012
Adults 40 years of age and older have been shown to be hypo-responsive immunologically to the currently available hepatitis B virus (HBV) vaccines. Three intramuscular doses of a Toll-like receptor 9 agonist, 1018 immunostimulatory sequence (1018 ISS ...
안상훈
core  

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity [PDF]

, 2006
Background: MHC Class I molecules present antigenic peptides to cytotoxic T cells, which forms an integral part of the adaptive immune response. Peptides are bound within a groove formed by the MHC heavy chain. Previous approaches to MHC Class I-peptide
Hattotuwagama, C.K., Moss, David S., Davies, M.N., David S Moss, Drew, M.G.B., Channa K Hattotuwagama, Drew, Michael G.B., Flower, Darren R., Matthew N Davies, Hattotuwagama, Channa K., Davies, Matthew N., Michael GB Drew, Darren R Flower, Flower, D.R., Moss, D.S.   +14 more
core   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Malaria immunology and vaccine development

, 2008
This thesis describes work undertaken by the author at the University of Oxford. Itbegins by providing an introduction to malaria infection and pathophysiology, anda review of the latest attempts to produce an effective malaria vaccine.
Thompson, Fiona Mary
core   +1 more source

Characterization of vaccine antigens of meningococcal serogroup W isolates from Ghana and Burkina Faso from 2003 to 2009 [PDF]

, 2014
Neisseria meningitidis is a major cause of bacterial meningitis and a considerable health problem in the 25 countries of the 'African Meningitis Belt' that extends from Senegal in West Africa to Ethiopia in the East.
Calman MacLennan, Gerd Pluschke, Koeberling, Oliver, Oliver Koeberling, Ispasanie, Emma, MacLennan, Calman, Emma Ispasanie, Ali Sie, Abraham Hodgson, Pluschke, Gerd, Hodgson, Abraham, Sie, Ali   +11 more
core   +1 more source