Results 121 to 130 of about 939,420 (304)

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Vaccine-induced peptide specific CD8⁺ T cell cytokine responses across the period of vaccination.

, 2019
Vaccine-induced peptide specific CD8+ T cell cytokine responses across the period of vaccination.
Sathyamurthy Pattabiram (6523958), Kannan Thiruvengadam (796402), Sriram Kumar (4566229), Jill Gilmour (10465), Shweta Chatrath (6523961), Rajat Goyal (281619), Joyeeta Mukherjee (112892), Sudha Subramaniam (6523967), Philip Bergin (455930), Malathy Muthu (6523964), Jakub T. Kopycinski (221464), Nikhil Singla (5698811), Sivasankaran Munusamy Ponnan (5698793), Srikanth Prasad Tripathy (3846424), Hanna Elizabeth Luke (5724728), Soumya Swaminathan (110137)   +15 more
core   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Development of a candidate mRNA vaccine based on Multi-Peptide targeting VP4 of rotavirus A: an immunoinformatics and molecular dynamics approach

Scientific Reports
Rotavirus (RV) is a common double-stranded RNA virus that causes diarrheal disease in young children. The prevalent species, Rotavirus A (RVA), is responsible for over 90% of human RV infections.
Cena Aram, Leila Karami, Mohammad Mehdi Ranjbar   +2 more
doaj   +1 more source

Vaccine-induced peptide specific CD4⁺ T cell cytokine responses across the period of vaccination.

, 2019
Vaccine-induced peptide specific CD4+ T cell cytokine responses across the period of vaccination.
Sathyamurthy Pattabiram (6523958), Kannan Thiruvengadam (796402), Sriram Kumar (4566229), Jill Gilmour (10465), Shweta Chatrath (6523961), Rajat Goyal (281619), Joyeeta Mukherjee (112892), Sudha Subramaniam (6523967), Philip Bergin (455930), Malathy Muthu (6523964), Jakub T. Kopycinski (221464), Nikhil Singla (5698811), Sivasankaran Munusamy Ponnan (5698793), Srikanth Prasad Tripathy (3846424), Hanna Elizabeth Luke (5724728), Soumya Swaminathan (110137)   +15 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Receptor binding domain-independent pancoronavirus vaccine design by fusion of conserved T/B Epitopes

Emerging Microbes and Infections
The persistent emergence of SARS-CoV-2 variants continues to compromise current vaccine efficacy, driving the development of broad-spectrum coronavirus vaccines to address variant evasion and future outbreaks.
Yunru Yang, Yetian Chen, Mengyu Hong, Ronghua Zou, Jingxue Yao, Entao Li, Jiayi Wang, Xiaodong Ye, Yixiang Xing, Yangming Tang, Xiaojie Lu, Chengchao Ding, Hongliang He, Dali Tong, Yuhua Shang, Jian Wang, Guangyu Zhao, Xiaoxue Huang, Fuli Feng, Qingyu Cheng, Bofeng Li, Baoying Huang, Wenjie Tan, Sandra Chiu, Tengchuan Jin   +24 more
doaj   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source