Results 191 to 200 of about 939,420 (304)

MtrE Loop2-specific multiple antigenic peptide vaccine and monoclonal antibody confer complement-dependent protection against Neisseria gonorrhoeae. [PDF]

NPJ Vaccines
Song S, Ge H, Yuan D, Gu X, Lu W, Ding C, Qin Y, Gao S, Lin X, Cheng H, van der Veen S.   +10 more
europepmc   +1 more source

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

Chemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak, Huy N. Hoang, Wael Awad, Xin Yi Lim, Damica D. Laurie, Ryan J. D. Rivero, James McCluskey, Alexandra J. Corbett, Jamie Rossjohn, David P. Fairlie   +9 more
wiley   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

An integrated subtractive genomics and immunoinformatic approach for designing a multi-epitope peptide vaccine against methicillin-resistant Staphylococcus aureus. [PDF]

Front Bioinform
Subramani NK, Venugopal S, Rajan AP.
europepmc   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Peptide vaccine formulations with structurally distinct STING agonist drugamers induce discrete, efficacious antitumor responses. [PDF]

Proc Natl Acad Sci U S A
Song K, Nguyen DC, Wang Y, Jokonya S, Yazdani O, Sellers DL, Stayton PS, Pun SH.   +7 more
europepmc   +1 more source

Cross‐protective effect of a multicomponent fusion protein vaccine during a natural episode of Streptococcus zooepidemicus respiratory disease in ponies

Equine Veterinary Journal, EarlyView.
Abstract Background Streptococcus equi subspecies zooepidemicus is a highly diverse opportunistic pathogen of horses, associated with respiratory disease and endometritis. Objectives To characterise S. zooepidemicus isolates recovered from young ponies during a natural episode of respiratory disease, and to determine if vaccination with Strangvac®, a ...
Romain Paillot, J. Richard Newton, Sonia Gonzalez Medina, Sara Frosth, Lars Frykberg, Margareta Flock, Bengt Guss, Jan‐Ingmar Flock, Andrew S. Waller   +8 more
wiley   +1 more source

Multi-Epitope-Based Peptide Vaccine Against Bovine Parainfluenza Virus Type 3: Design and Immunoinformatics Approach. [PDF]

Vet Sci
Wang J, Wang P, Tian F, Liu Q, Hai M, Guo Z, Wang Y, Li Y, Wang Y.   +8 more
europepmc   +1 more source

Genetic variants of EcPV2 E6 and E7 in equine genital and oronasal squamous cell carcinoma

Equine Veterinary Journal, EarlyView.
Abstract Background Since its discovery in 2008, equine papillomavirus type 2 (EcPV2) has been detected in up to 100% of equine genital and up to 40% of equine oronasal squamous cell carcinomas (SCCs). Preliminary sequence data point to the existence of EcPV2 E6 and E7 oncogene variants compared to the British reference sequence from 2008.
Maya Jenner, Sabine Brandt
wiley   +1 more source

Proteogenomic approach to immunopeptidomics of ovarian tumors identifies shared peptide vaccine candidates. [PDF]

NPJ Vaccines
Chiaro J, Peltonen K, Õunap K, Bailey A, Feola S, Wojciechowski S, Es-Haghi M, Azkargorta M, Elortza F, Russo S, Sallinen H, Anttila M, Gurvich O, Cerullo V, Kekarainen T.   +14 more
europepmc   +1 more source