Results 131 to 140 of about 2,534,576 (425)
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Discovery of Proteomics based on Machine learning [PDF]
arXiv, 2013 The ultimate target of proteomics identification is to identify and quantify the protein in the organism. Mass spectrometry (MS) based on label-free protein quantitation has mainly focused on analysis of peptide spectral counts and ion peak heights. Using several observed peptides (proteotypic) can identify the origin protein.
arxiv
Peptidomic and glycomic profiling of commercial dairy products: identification, quantification and potential bioactivities. [PDF]
, 2019 Peptidomics and glycomics are recently established disciplines enabling researchers to characterize functional characteristics of foods at a molecular level.
Barile, Daniela +4 more
core +2 more sources
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Retention Time of Peptides in Liquid Chromatography Is Well Estimated upon Deep Transfer Learning [PDF]
arXiv, 2017 A fully automatic prediction for peptide retention time (RT) in liquid chromatography (LC), termed as DeepRT, was developed using deep learning approach, an ensemble of Residual Network (ResNet) and Long Short-Term Memory (LSTM). In contrast to the traditional predictor based on the hand-crafted features for peptides, DeepRT learns features from raw ...
arxiv
The cooperative behaviour of antimicrobial peptides in model membranes [PDF]
, 2014 A systematic analysis of the hypothesis of the antimicrobial peptides' (AMPs) cooperative action is performed by means of full atomistic molecular dynamics simulations accompanied by circular dichroism experiments.
Andrei V. Zvelindovsky +62 more
core +1 more source
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
First Generic Teriparatide: Structural and Biological Sameness to Its Reference Medicinal Product
PharmaceuticsTeriparatide is an anabolic peptide drug indicated for the treatment of osteoporosis. Recombinant teriparatide was first approved in 2002 and has since been followed by patent-free alternatives under biosimilar or hybrid regulatory application.
Jimena Fernández-Carneado +11 more
doaj +1 more source
Virology Journal, 2019 In the original publication of this article [1], two grants from National Science Foundation of China and Yunnan Provincial Government (U1602226) and by National Science Foundation of China (2016YFC1200404) were omitted in the ‘Funding’ section.
Benxia Hu +6 more
doaj +1 more source