Results 141 to 150 of about 2,534,576 (425)

Characterisation of antibacterial peptides from the venom of Cupiennius salei (Araneae: Ctenidae). Diplomarbeit am Zoologischen Institut der Universität Bern, 19 S. [PDF]

, 2013
The characterisation of the antimicrobial activity of six antibacterial peptides, isolated from the venom of the neotropical wandering spider Cupiennius salei is reported.
Haeberli, Stefanie
core  

Collagen-mimetic peptide-modifiable hydrogels for articular cartilage regeneration [PDF]

, 2015
Regenerative medicine strategies for restoring articular cartilage face significant challenges to recreate the complex and dynamic biochemical and biomechanical functions of native tissues.
Chow, LW, Horejs, C-M, Parmar, PA, Peng, YY, Ramshaw, JAM, St-Pierre, J-P, Stevens, MM, Werkmeister, JA   +7 more
core   +2 more sources

Evaluation of the use of therapeutic peptides for cancer treatment

Journal of Biomedical Sciences, 2017
Cancer along with cardiovascular disease are the main causes of death in the industrialised countries around the World. Conventional cancer treatments are losing their therapeutic uses due to drug resistance, lack of tumour selectivity and solubility and
Susan Marqus, E. Pirogova, T. Piva
semanticscholar   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Comprehensive Mapping of Cyclotides from Viola philippica by Using Mass Spectrometry-Based Strategy

Molecules
Cyclotides are plant cyclic peptides with exceptional stability and diverse bioactivity, making them promising candidates for biomedical applications. Therefore, the study of cyclotides has attracted increasing attention in recent years.
Liyan Yu, Hailiang Pan, Xiaohang Chen, Shan Gong, Qipeng Zhang, Yandong Zhang, Zhajun Zhan   +6 more
doaj   +1 more source

Crystal structure of N-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C20H37N3O4, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer.
Andrzej Czerwinski, Channa Basava, Miroslawa Dauter, Zbigniew Dauter   +3 more
doaj   +1 more source

Peptides with Dual Antimicrobial and Anticancer Activities

Frontiers in Chemistry, 2017
In recent years, the number of people suffering from cancer and multi-resistant infections has increased, such that both diseases are already seen as current and future major causes of death.
Mário R Felício, O. N. Silva, Sónia Gonçalves, N. Santos, O. Franco   +4 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Structural Stability and Immunogenicity of Peptides [PDF]

arXiv, 2010
We investigated the role of peptide folding stability in peptide immunogenicity. It was the aim of this thesis to implement a stability criterion based on energy computations using an AMBER force field, and to test the implementation with a large dataset.
arxiv  

Polylactic Glycolic Acid-Mediated Delivery of Plectasin Derivative NZ2114 in Staphylococcus epidermidis Biofilms

Antibiotics
Antimicrobial peptides (AMPs) are antibiotic candidates; however, their instability and protease susceptibility limit clinical applications. In this study, the polylactic acid–glycolic acid (PLGA)–polyvinyl alcohol (PVA) drug delivery system was screened
Xuanxuan Ma, Na Yang, Ruoyu Mao, Ya Hao, Da Teng, Yinhua Huang, Jianhua Wang   +6 more
doaj   +1 more source