Results 211 to 220 of about 1,357,535 (259)
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Peptide Vaccines and Peptide Libraries
Biological Chemistry, 2001Synthetic immunogens, containing built-in adjuvanticity, B cell, T helper cell and CTL epitopes or mimotopes, are ideal and invaluable tools to study the immune response with respect to antigen processing and presentation. This serves as a basis for the development of complete and minimal vaccines which do not need large carrier proteins, further ...
Karl-Heinz Wiesmüller +2 more
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Unprotected peptides as building blocks for branched peptides and peptide dendrimers
International Journal of Peptide and Protein Research, 1995We describe two new site‐specific ligation methods for preparing branched peptide dendrimers such as multiple antigen peptide (MAP). Both methods are based on the general approach of exploiting the specific reaction between a weak base and an aldehyde under acidic conditions so that unprotected peptides can be used as building blocks.
James P. Tam, Jane C. Spetzler
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Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics
Bioorganic & Medicinal Chemistry, 2018The development of solid phase peptide synthesis has released tremendous opportunities for using synthetic peptides in medicinal applications. In the last decades, peptide therapeutics became an emerging market in pharmaceutical industry. The need for synthetic strategies in order to improve peptidic properties, such as longer half-life, higher ...
Miloš Erak +3 more
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Journal of Peptide Science, 1998
Siderophores are low molecular weight iron chelators, produced by virtually all bacteria, fungi and some plants. They serve to deliver the essential element iron, barely soluble under aerobic conditions, into microbial cells. Siderophores are therefore important secondary metabolites which are very often based on amino acids and their derivatives ...
G. Jung, H. Drechsel
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Siderophores are low molecular weight iron chelators, produced by virtually all bacteria, fungi and some plants. They serve to deliver the essential element iron, barely soluble under aerobic conditions, into microbial cells. Siderophores are therefore important secondary metabolites which are very often based on amino acids and their derivatives ...
G. Jung, H. Drechsel
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Atrial natriuretic peptide and related peptides
Clinical Chemical Laboratory Medicine, 2007AbstractIn recent years, biomarkers have been recognized as important tools for diagnosis, risk stratification, and therapeutic decision-making in cardiovascular diseases. Currently, the clinical potential of several natriuretic peptides is under scientific investigation.
Akashi, Yoshihiro J. +3 more
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Life Sciences, 1973
Evidence has accumulated that peptides influence behavior by acting on various structures in the brain. Peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitary have been shown to modulate conditioned behavior (DE WIED, 1969).
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Evidence has accumulated that peptides influence behavior by acting on various structures in the brain. Peptides derived from the anterior pituitary (ACTH, growth hormone), the intermediate lobe (α-MSH), and the posterior lobe (vasopressin) of the pituitary have been shown to modulate conditioned behavior (DE WIED, 1969).
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Archives of Physiology and Biochemistry, 2002
Corticotrophs were long thought to be a static, homogeneous population of cells that respond positively to hypothalamic stimulation, are inhibited by glucocorticoid feedback and secrete a single biologically active peptide, ACTH(1-39). Our current understanding is that this is an oversimplification and corticotrophs are a dynamic and more complex group
Schwartz, J. +5 more
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Corticotrophs were long thought to be a static, homogeneous population of cells that respond positively to hypothalamic stimulation, are inhibited by glucocorticoid feedback and secrete a single biologically active peptide, ACTH(1-39). Our current understanding is that this is an oversimplification and corticotrophs are a dynamic and more complex group
Schwartz, J. +5 more
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Selection and application of peptide-binding peptides
Nature Biotechnology, 2000Peptide-binding ligands would be useful for directing reagents to particular epitopes in a protein, the detection of peptide hormones, and many other applications. Here we show that peptides of modest size isolated from a library using a simple genetic assay can act as specific receptors for other peptides.
Weiguang Zhu +2 more
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1995
If we include beta-lactam antibiotics on the grounds that they have the same biosynthetic origin, peptides remain commercially the most important group of pharmaceuticals. However, our increasing knowledge of the genetic and enzymic background to biosynthesis, and of the regulation of metabolite production, will eventually bring a more unified approach
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If we include beta-lactam antibiotics on the grounds that they have the same biosynthetic origin, peptides remain commercially the most important group of pharmaceuticals. However, our increasing knowledge of the genetic and enzymic background to biosynthesis, and of the regulation of metabolite production, will eventually bring a more unified approach
openaire +3 more sources