INVESTIGATIONS OF AMINO ACIDS, PEPTIDES, AND PROTEINS
Max S. Dunn+4 more
openalex +1 more source
A Comparison of the Mechanical Properties of ECM Components and Synthetic Self‐Assembling Peptides
Self‐assembling peptide hydrogels are increasingly utilized in biomedical applications. The authors review the key mechanical properties of these structures across multiple size scales and compare them to that of native extracellular matrix components, which are found to display a much wider range of structural attributes.
Alex Hartley+2 more
wiley +1 more source
Esc peptides and derivatives potentiate the activity of CFTR with gating defects and display antipseudomonal activity in cystic fibrosis-like lung disease. [PDF]
Ferrera L+13 more
europepmc +1 more source
FXa‐Responsive Hydrogels to Craft Corneal Endothelial Lamellae
This study introduces a sacrificial, multicomponent biohybrid hydrogel system enabling stable scaffold‐free tissue engineering. Its efficacy is demonstrated through the ex vivo development, detachment, and transplantation of human corneal endothelial lamellae, achieving clinically relevant sizes for Descemet Membrane Endothelial Keratoplasty.
Mikhail V. Tsurkan+7 more
wiley +1 more source
Unravelling the Glycan Code: Molecular Dynamics and Quantum Chemistry Reveal How O-Glycan Functional Groups Govern OgpA Selectivity in Mucin Degradation by Akkermansia muciniphila. [PDF]
Khavani M, Mehranfar A, Mofrad MRK.
europepmc +1 more source
The ability of human induced pluripotent stem cells (hiPSCs) to model developmental processes makes them a promising source for engineering testicular tissues to study in vitro maturation and sperm production. This work describes the first hiPSC‐derived testicular model and shows that it captures functional aspects of prepubertal testicular tissues ...
Meghan A Robinson+15 more
wiley +1 more source
Enhancing Antimicrobial Peptides from Frog Skin: A Rational Approach. [PDF]
Aguilar S+13 more
europepmc +1 more source
The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden+5 more
wiley +1 more source
The immunopeptidome of colon cancer cells treated with topoisomerase inhibiting drug reveals differential as well as common endogenous protein sampling and display of MHC I-associated peptides. [PDF]
Bedi D+5 more
europepmc +1 more source