Small local populations of bacteria are often involved in bacterial infections; however, bulk susceptibility assays guide antibiotic treatment decisions. Furthermore, during the early and late stages of treatment, these small bacterial populations are exposed to sub‐inhibitory concentrations of antibiotics.
Ashkan Samimi +3 more
wiley +1 more source
The effect of MurM and a branched cell wall structure on penicillin resistance in <i>Streptococcus pneumoniae</i>. [PDF]
Gjennestad RS +7 more
europepmc +1 more source
Infected diabetic foot ulcer endangers patients with high amputation, disability, mortality risks, and heavy medical burdens. This review analyzes its pathogenic factors, the limitations of current treatments, the breakthroughs of responsive antimicrobial biomaterials, and the challenge of multifunctional biomaterial innovations for further developing ...
Yaqi Yao +8 more
wiley +1 more source
<i>Macleaya cordata</i> Alkaloids Sanguinarine and Chelerythrine Inhibit <i>Nocardia seriolae</i> by Disrupting Cell Envelope Integrity and Energy Metabolism: Insights from Transcriptomic Analysis. [PDF]
Huang L +9 more
europepmc +1 more source
A characteristic of many neurodegenerative disorders, such as Parkinson’s and Alzheimer’s, is amyloidogenic protein aggregation, for which there are currently no proven cures. Aging, mutation, and physiological stress can cause proteins to deviate from their natural folding patterns, potentially leading to the formation of hazardous protein aggregates.
Md. Tauqir Alam +4 more
wiley +1 more source
Lipid II unlocked: strategies for obtaining a major antibiotic target.
Tyrie LJ, Karak M, Cochrane SA.
europepmc +1 more source
Visualization of peptidoglycan layer isolated from gliding diderm bacteria, <i>Flavobacterium johnsoniae</i> and <i>Myxococcus xanthus</i>, by quick-freeze deep-etch replica electron microscopy. [PDF]
Tahara YO, Mignot T, Miyata M.
europepmc +1 more source
ABSTRACT Porphyromonas gingivalis is a typical periodontal pathogen, and one of its key virulence factors is the powerful protease gingipains. Gingipains are secreted via the type IX secretion system (T9SS) and are associated with the assembly and insertion machinery (Aim) operon (PGN_0296 to PGN_0301), which encodes both T9SS components and non‐T9SS ...
Shintaro Ono +7 more
wiley +1 more source
Probing the mechanism of peptidoglycan amidase activation by FtsEX-EnvC. [PDF]
Cook J, Crow A.
europepmc +1 more source
Relating corynebacterial cell envelope layers to its biochemical and physical properties. [PDF]
Modak M +4 more
europepmc +1 more source

