Results 71 to 80 of about 101,965 (169)

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

Premature Occlusal Contacts Induce MRONJ in Osseointegrated Dental Implants: An Experimental In Vivo Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives Medication‐related osteonecrosis of the jaw (MRONJ) is a debilitating condition associated with antiresorptive agents (ARAs) and can occur around well‐osseointegrated dental implants. Although implant presence–triggered osteonecrosis (IPTO) has been primarily linked to bacteria‐related peri‐implantitis, whether occlusal trauma ...
Eun‐Bin Bae, Ahana Goswami, Jun Yaung, Soo Yeon Kim, Sherry S. Baik, Kaylyn A. Yu, Chan Park, Jung‐Bo Huh, Jae‐Young Kim, Christine Y. Hong, Sol Kim, Reuben H. Kim   +11 more
wiley   +1 more source

Geographic Variation and Core Signatures of the Root Canal Microbiome: A Cross‐Country Comparative Study

International Endodontic Journal, EarlyView.
ABSTRACT Aim Root canal infections harbour complex microbial communities that may vary across geographic populations. This study aimed to compare the root canal microbiome across Spain, Sweden, and the USA, identifying key microbial taxa, compositional and functional differences, and cohort‐associated microbial signatures.
Naorem Leimarembi Devi, Olena Rakhimova, Christopher Staley, Ronald Ordinola‐Zapata, Maria Teresa Arias Moliz, Virginia Pérez‐Carrasco, Nelly Romani Vestman   +6 more
wiley   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Isolation and Identification of Erysipelothrix sp. in Hybrid Grouper (Epinephelus fuscoguttatus × E. lanceolatus) in Taiwan

Journal of Fish Diseases, EarlyView.
ABSTRACT In February 2025, a mortality event of unknown aetiology occurred at a hybrid grouper (Epinephelus fuscoguttatus × Epinephelus lanceolatus) aquaculture farm in southern Taiwan, with sporadic daily deaths persisting for a month. Four moribund groupers were collected over three sampling intervals for diagnostic investigation.
Shang‐Ting Wu, Yu‐Siang Lin, Chia‐Yu Hsieh   +2 more
wiley   +1 more source

How AFM has contributed to the understanding of bacterial cell wall peptidoglycan structure

Journal of Microscopy, EarlyView.
Abstract The bacterial cell wall is an essential exoskeleton that plays a major role in conferring cell shape, serving as the primary stress‐bearing layer, resisting the several atmospheres turgor pressure created by the imbalance in molecular concentrations between the cell interior and the surrounding medium, while also playing a central role in host‐
Abimbola Feyisara Adedeji‐Olulana, Ankita Ray, Timothy Chester‐Parsons, Alexander Knight, Alexander I. Tartakovskii, Simon Foster, Jamie K. Hobbs   +6 more
wiley   +1 more source

Ariadnema polymorpha gen. et sp. nov. (Scytonemataceae, Cyanobacteria): A new heterocytous cyanobacterium with true and false branching from ruins in the Brazilian Atlantic Forest

Journal of Phycology, EarlyView.
Abstract A novel heterocytous Cyanobacterium, Ariadnema polymorpha gen. et sp. nov., was observed in the northern Brazilian Atlantic Forest (BAF), a globally significant biodiversity hotspot that has microbiome diversity yet to be explored. Isolated from ancient sugarcane mill ruins within the BAF, the new genus (strain CCAPE130) exhibits a unique ...
Jefferson Vitor Melo Cabral, Haywood Dail Laughinghouse IV, Jonatas Mota Paulino, Watson Arantes Gama   +3 more
wiley   +1 more source

Recognition of pathogenic bacteria by intestinal stem cells promotes adult Drosophila midgut regeneration. [PDF]

PLoS Biol
Uttekar B, Srotyr M, Ravale SS, Ewertowska L, Wafer R, Legido M, Patel PH.   +6 more
europepmc   +1 more source

Genome‐scale insights into metabolic streamlining and photosynthetic energy balance in the extremophile green alga Picocystis salinarum (Picocystophyceae, Chlorophyta)

Journal of Phycology, EarlyView.
Abstract Picocystis salinarum is an early‐diverging chlorophyte and the sole described member of the Picocystophyceae, frequently dominating hypersaline and alkaline lakes despite extreme physicochemical constraints. To elucidate the genomic foundations of its ecological success, we generated a fully annotated, chromosome‐scale nuclear genome assembly ...
Claude Lemieux, Christian Otis, Monique Turmel   +2 more
wiley   +1 more source