Results 211 to 220 of about 87,420 (248)

The structural peptidoglycan hydrolase gp181 of bacteriophage φKZ

Biochemical and Biophysical Research Communications, 2008
Gp181 (2237 amino acids) of Pseudomonas aeruginosa bacteriophage phiKZ (Myoviridae) is a structural virion protein, which bears a peptidoglycan hydrolase domain near its C-terminus. This protein is supposed to degrade the peptidoglycan locally during the infection process.
Vadim V. Mesyanzhinov, Konstantin A. Miroshnikov, O. V. Chertkov, Guido Volckaert, Rob Lavigne, Alexei N. Nekrasov, Yves Briers   +6 more
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Peptidoglycan Hydrolases ofBacillus subtilis168

Microbial Drug Resistance, 1996
There are multiple peptidoglycan hydrolases associated with Bacillus subtilis 168 and these potentially lethal enzymes have been implicated in a number of important cellular processes. Several enzymes have been studied at the molecular level and their structural genes characterized. This information has begun to identify roles for individual enzymes in
Stephen A. Blackman, Thomas J. Smith, Simon J. Foster   +2 more
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Measure of Peptidoglycan Hydrolase Activity

2017
Most gene clusters encoding multiprotein complexes of the bacterial cell envelope, such as conjugation and secretion systems, Type IV pili, and flagella, bear a gene encoding an enzyme with peptidoglycan hydrolase activity. These enzymes are usually glycoside hydrolases that cleave the glycan chains of the peptidoglycan.
Eric Cascales, Yoann G. Santin
openaire   +3 more sources

In-silico analysis of peptidoglycan hydrolases from Serratia marcescens and other Serratia species

Int. J. Comput. Biol. Drug Des., 2020
Bacteria possess a protective extracytoplasmic glycopeptide polymer, i.e., peptidoglycan. In case of Gram-positive bacteria, it acts as scaffolds to many virulence factors whereas in Gram-negative bacteria, it serves as an anchor to outer membrane.
Aditi Rathee, K. Gupta, S. Kumari, S. Chhibber, Ashok Kumar   +4 more
semanticscholar   +1 more source

Peptidoglycan hydrolases in an autolytic mutant of Salmonella typhimurium

Archives Internationales de Physiologie et de Biochimie, 1988
Two peptidoglycan hydrolases were isolated from the autolytic mutant Salmonella typhimurium DA361 (envD). One of them, resistant to penicillin, was found free in the supernatant of partially purified envelopes sedimented by ultracentrifugation, and the other bound to the envelopes proved to be sensitive to the antibiotic. Both were able to hydrolyse in
R O Fernández, L V Orce, R A Pizarro
openaire   +3 more sources

Identification of a novel peptidoglycan hydrolase CwlM in Mycobacterium tuberculosis

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005
Mycobacterium tuberculosis is a major global pathogen whose threat has increased with the emergence of multidrug-resistant strains. The cell wall of M. tuberculosis is thick, rigid, and hydrophobic, which serves to protect the organism from the environment and makes it highly impermeable to conventional antimicrobial agents. There is little known about
Robert D. Arbeit, Donald E. Humphries, Lingyi Lynn Deng, Sandra C. Smole, J. David Carroll, Laura E. Carlton   +5 more
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Biochemical analysis of NlpC/p60 peptidoglycan hydrolase activity

2020
The NlpC/p60-family of peptidoglycan hydrolases are key enzymes that facilitate bacterial cell division and also modulate microbe-host interactions. These endopeptidases utilize conserved Cys-His residues in their active site and are expressed in most bacterial species as well as some eukaryotes.
Howard C. Hang, Juliel Espinosa, Byungchul Kim   +2 more
openaire   +3 more sources

Proteins of the Rpf (resuscitation promoting factor) family are peptidoglycan hydrolases [PDF]

Biochemistry (Moscow), 2006
The secreted Micrococcus luteus protein, Rpf, is required for successful resuscitation of dormant "non-culturable" M. luteus cells and for growth stimulation in poor media. The biochemical mechanism of Rpf action remained unknown. Theoretical predictions of Rpf domain architecture and organization, together with a recent NMR analysis of the protein ...
Michael Young, Galina R. Demina, Galina V. Mukamolova, Galina V. Mukamolova, T V Dudik, Elena G. Salina, A. V. Goncharenko, T.N. Stekhanova, Arseny S. Kaprelyants, K. A. Kazaryan, S. A. Voloshin, M. V. Telkov   +11 more
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Structural Comparison and Simulation of Pneumococcal Peptidoglycan Hydrolase LytB

2016
Three-dimensional structural determination combined with comprehensive comparisons with the homologs is a straightforward strategy to decipher the molecular function of an enzyme. However, in many cases it's difficult to obtain the complex structure with the substrate/ligand.
Jing-Ren Zhang, Cong-Zhao Zhou, Yong-Liang Jiang, Qiong Li, Yuxing Chen, Xiao-Hui Bai, Xiao-Hui Bai   +6 more
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Chapter 7 Microbial peptidoglycan (murein) hydrolases

1994
Publisher Summary This chapter discusses the microbial peptidoglycan (murein) hydrolases. Studies of the action of lysozyme and of other bacteriolytic enzymes revealed that the bacteriolytic action was a result of hydrolysis of specific bonds in the protective and shape-maintaining bacterial exoskeleton, the peptidoglycan (murein) sacculus of the ...
G.D. Shockman, J.-V. Höltje
openaire   +2 more sources