Results 91 to 100 of about 5,000 (140)

Hydrolysis of enkephalin by cultured human endothelial cells and by purified peptidyl dipeptidase

Biochemical Pharmacology, 1978
Abstract : The experiments indicate that rapid inactivation of enkephalins may be due to at least two different enzymes present in tissues. A peptidyl dipeptidase which is a component of plasma membrane of various cells may degrade enkephalins by liberating a C-terminal dipeptide and an aminopeptidase in endothelial cells may cleave peptides, that they
A R Johnson, Alice R Johnson, E G Erdos
exaly   +3 more sources

Determination of peptidyl dipeptidase activity in 24 bacterial species

Canadian Journal of Microbiology, 1990
Of 24 bacterial species examined for lisinopril refractive peptidyl dipeptidase activity, only 8 contained activity. Activity in Pseudomonas maltophilia was more than fourfold higher than that of any other species. Pseudomonas maltophilia may be unique among bacteria in possessing high peptidyl dipeptidase activity that is both EDTA inhibitable and ...
Joseph J Lanzillo, Barry L Fanburg, B L Fanburg   +2 more
exaly   +3 more sources

Amino acid residues essential for catalysis by peptidyl dipeptidase-4 from pseudomonas maltophilia

Biochemical and Biophysical Research Communications, 1989
To assess residues essential for catalysis by prokaryotic peptidyl dipeptidase-4, the enzyme was subjected to chemical modification by a series of reagents. Treatment with either tetranitromethane or N-acetylimidazole abolished catalytic activity. Hydroxylamine reversed inactivation by acetylimidazole only.
Joseph J Lanzillo, Barry L Fanburg, B L Fanburg   +2 more
exaly   +3 more sources

Detection of essential arginine in bacterial peptidyl dipeptidase-4: Arginine is not the anion binding site

Biochemical and Biophysical Research Communications, 1989
Peptidyl dipeptidase-4 from Pseudomonas maltophilia was modified with the arginine reagents p-hydroxyphenylglyoxal and 2,3-butanedione. The enzyme was inactivated in a pseudo-first-order manner by p-hydroxyphenylglyoxal with a half-time of 72 min. Inactivation by 2,3-butanedione was biphasic with a rapid phase followed by a slower inactivation to less ...
Joseph J Lanzillo, Barry L Fanburg, B L Fanburg   +2 more
exaly   +3 more sources

A distinct peptidyl dipeptidase that degrades enkephalin: Exceptionally high activity in rabbit kidney

Life Sciences, 1981
Abstract Peptidyl dipeptidase activity distinct from the angiotensin converting enzyme (EC 3.4.15.1) was isolated from membrane fractions of rabbit kidney and lung. The enzyme cleaved Leu-enkephalin at the Gly-Phe bond, releasing Tyr-Gly-Gly and Phe-Leu, and also acted on bradykinin releasing the terminal dipeptide Phe-Arg.
N Marks, M J Berg, M J Berg
exaly   +3 more sources

Peptidyl-dipeptidase B

1998
Dietmar Schomburg, Dörte Stephan
exaly   +2 more sources

Peptidyl-Dipeptidase A (Invertebrate)

2013
R.E. Isaac, A.D. Shirras
exaly   +2 more sources

Peptidyl-Dipeptidase

2008
exaly   +2 more sources

Human erythrocytic prolyl endopeptidase II hydrolyzing teprotide, an inhibitor of snake venom peptidyl dipeptidase

Bulletin of Experimental Biology and Medicine, 1985
V N Orekhovich
exaly   +2 more sources

EFFECT OF PEPTIDYL‐DIPEPTIDASE INHIBITORS IN EXPERIMENTAL CONVULSIONS IN MICE

Fundamental & Clinical Pharmacology, 1987
Summary— The anticonvulsant effect of compounds that inhibit peptidyl‐dipeptidase (PDP) on bicuculline (BIC)‐ and strychnine (STRYC)‐induced seizures was assessed after intracerebroventricular (ICV) or intraperitoneal (IP) administration in Swiss albino mice.
F J, Miñano, J S, Serrano, M, Sancibrián, M I, Serrano   +3 more
openaire   +2 more sources