Expanded ribosomal synthesis of non-standard cyclic backbones in vitro
Nature CommunicationsThe ribosome polymerizes L-α-amino acids into polypeptides, catalyzing peptide bond formation through aminolysis. This process is facilitated by entropy trapping within its peptidyl transferase center (PTC).
Kanghun Lee +5 more
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Mapping of 23‐S rRNA at the Ribosomal Peptidyl‐Transferase Center by Photo‐Affinity Labeling [PDF]
, 1977 Nahum Sonenberg, Meir Wilchek, Ada Zamir
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The study of the stimulating mechanism of the peptidyl donor activity of 2′(3′)‐O‐(N‐formylmethionyl)‐adenosine‐5′‐phosphate in peptidyl transferase of E. coli ribosome [PDF]
, 1976 Alexander A. Krayevsky +6 more
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Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center
, 2006 Neuza Satomi Sato +4 more
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Affinity Labelling of 23‐S Ribosomal RNA in the Active Centre of Escherichia coli Peptidyl Transferase [PDF]
, 1974 P. Greenwell +2 more
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Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA‐Leu to 50 S subunits [PDF]
, 1971 M. L. Celma, R.E. Monro, D. Vázquez
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NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center. [PDF]
, 1995 Shuhui Wang +2 more
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Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis. [PDF]
Chem Sci, 2019 Tam B +9 more
europepmc +1 more source
Photoinactivation of peptidyl transferase binding sites
FEBS Letters, 1979 Černá, J., Rychlík, I.
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Peptidyl‐tRNA and peptidyl transferase activity of skeletal muscle ribosomes. Effect of diabetes [PDF]
FEBS Letters, 1970 Stirewalt, William S., Wool, Ira G.
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